Mammalian cells encode three D cyclins (D1, D2, and D3) that coordinately function as
allosteric regulators of cyclin-dependent kinase 4 (CDK4) and CDK6 to regulate cell cycle …

Forkhead box O (FOXO) transcription factors regulate diverse biological processes, affecting
development, metabolism, stem cell maintenance and longevity. They have also been …

Abstract The Animal Transcription Factor DataBase (AnimalTFDB) is a resource aimed to
provide the most comprehensive and accurate information for animal transcription factors …

Since the introduction of the cancer stem cell (CSC) paradigm, significant advances have
been made in understanding the functional and biological plasticity of these elusive …

Embryonic development is characterized by rapidly dividing cells, cellular plasticity and a
highly vascular microenvironment. These features are similar to those of tumour tissue, in …

Breast cancer stem cells (BCSCs) are tumor initiating cells that can self-renew and are
highly tumorigenic and chemoresistant. Therefore, the identification of factors critical for …

FOXM1 is a transcription factor required for a wide spectrum of essential biological functions,
including DNA damage repair, cell proliferation, cell cycle progression, cell renewal, cell …

Abstract Background Forkhead box M1 (FOXM1) is a proliferation-associated transcription
factor of the forkhead box proteins superfamily, which includes four isoforms FOXM1a, b, c …

While the transcription factor forkhead box M1 (FOXM1) is well known as a proto-oncogene,
its potential role in lung fibroblast activation has never been explored. Here, we show that …

Drug resistance is a major hurdle for successful treatment of breast cancer, the leading
cause of deaths in women throughout the world. The FOXM1 transcription factor is a potent …