Genome-scale metabolic models (GEMs) enable the mathematical simulation of the
metabolism of archaea, bacteria, and eukaryotic organisms. GEMs quantitatively define a …

Artificial Intelligence (AI) relies upon a convergence of technologies with further synergies
with life science technologies to capture the value of massive multi-modal data in the form of …

背景慢性病共病的情况在老年群体中较为常见,“多病共存” 已成为日益严重的公共卫生问题,
但目前我国老年人慢性病共病现状及共病模式研究相对缺乏. 目的分析我国老年人慢性病患病 …

Evolutionary phenotypic transitions, such as the fin-to-limb transition in vertebrates, result
from modifications in related proteins and their interactions, often in response to changing …

Background Depression is a psychiatric disorder with a high comorbidity burden; however,
previous comorbidity studies predominately focused on a few common diseases and relied …

Computational modeling has emerged as a critical tool in investigating the complex
molecular processes involved in biological systems and diseases. In this study, we apply …

Publications and patents have long been regarded as useful sources of technological
knowledge in the biomedical sector; thus, they have been analyzed to monitor technology …

Exploring multimorbidity relationships among diseases is of great importance for
understanding their shared mechanisms, precise diagnosis and treatment. However, the …

Background Within the global endeavour of improving population health, one major
challenge is the identification and integration of medical knowledge spread through several …

Intensive research efforts have been undertaken to slow human aging and therefore
potentially delay the onset of age-related diseases. These efforts have generated an …