Liver fibrosis is an advanced liver disease condition, which could progress to cirrhosis and
hepatocellular carcinoma. To date, there is no direct approved antifibrotic therapy, and …

Hepatic fibrosis is a dynamic process characterized by the net accumulation of extracellular
matrix resulting from chronic liver injury of any aetiology, including viral infection, alcoholic …

Liver fibrosis and in particular cirrhosis are the major causes of morbidity and mortality of
patients with chronic liver disease. Their prevention or reversal have become major …

Liver cancer is the second leading cause of cancer mortality worldwide, causing more than
700,000 deaths annually. Because of the wide landscape of genomic alterations and limited …

Histological fibrosis stage is one of the most important prognostic factors in compensated
and decompensated alcohol-related liver disease (ALD). Morphological assessment of …

Liver fibrosis is the excessive accumulation of extracellular matrix proteins including
collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

Liver fibrosis is a major cause of morbidity and mortality worldwide due to chronic viral
hepatitis and, more recently, from fatty liver disease associated with obesity. Hepatic stellate …

Liver fibrosis has evolved in the past 20 years from a pure laboratory discipline to an area of
great bedside relevance to practicing hepatologists. This evolution reflects growing awarenessnotonlyofthemolecularunderpinn …