The molecular virology of coronaviruses

E Hartenian, D Nandakumar, A Lari, M Ly… - Journal of Biological …, 2020 - ASBMB
Few human pathogens have been the focus of as much concentrated worldwide attention as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its …

Coronavirus envelope protein: current knowledge

D Schoeman, BC Fielding - Virology journal, 2019 - Springer
Abstract Background Coronaviruses (CoVs) primarily cause enzootic infections in birds and
mammals but, in the last few decades, have shown to be capable of infecting humans as …

Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein

J Lei, Y Kusov, R Hilgenfeld - Antiviral research, 2018 - Elsevier
The multi-domain non-structural protein 3 (Nsp3) is the largest protein encoded by the
coronavirus (CoV) genome, with an average molecular mass of about 200 kD. Nsp3 is an …

Membrane binding proteins of coronaviruses

EA J Alsaadi, IM Jones - Future Virology, 2019 - Taylor & Francis
Coronaviruses (CoVs) infect many species causing a variety of diseases with a range of
severities. Their members include zoonotic viruses with pandemic potential where …

Severe acute respiratory syndrome coronavirus nonstructural proteins 3, 4, and 6 induce double-membrane vesicles

MM Angelini, M Akhlaghpour, BW Neuman… - MBio, 2013 - Am Soc Microbiol
Coronaviruses (CoV), like other positive-stranded RNA viruses, redirect and rearrange host
cell membranes for use as part of the viral genome replication and transcription machinery …

[HTML][HTML] Coronavirus envelope (E) protein remains at the site of assembly

P Venkatagopalan, SM Daskalova, LA Lopez… - Virology, 2015 - Elsevier
Coronaviruses (CoVs) assemble at endoplasmic reticulum Golgi intermediate compartment
(ERGIC) membranes and egress from cells in cargo vesicles. Only a few molecules of the …

Expression and cleavage of middle east respiratory syndrome coronavirus nsp3-4 polyprotein induce the formation of double-membrane vesicles that mimic those …

D Oudshoorn, K Rijs, RWAL Limpens, K Groen… - MBio, 2017 - Am Soc Microbiol
ABSTRACT Betacoronaviruses, such as Middle East respiratory syndrome coronavirus
(MERS-CoV), are important pathogens causing potentially lethal infections in humans and …

Unique mutations in SARS-CoV-2 Omicron subvariants' non-spike proteins: Potential impacts on viral pathogenesis and host immune evasion

A Hossain, S Akter, AA Rashid, S Khair… - Microbial …, 2022 - Elsevier
SARS-CoV-2 is the causative agent behind the ongoing COVID-19 pandemic. This virus is a
cumulative outcome of mutations, leading to frequent emergence of new variants and their …

[HTML][HTML] Two-amino acids change in the nsp4 of SARS coronavirus abolishes viral replication

Y Sakai, K Kawachi, Y Terada, H Omori, Y Matsuura… - Virology, 2017 - Elsevier
Infection with coronavirus rearranges the host cell membrane to assemble a replication/
transcription complex in which replication of the viral genome and transcription of viral …

Understanding COVID-19 via comparative analysis of dark proteomes of SARS-CoV-2, human SARS and bat SARS-like coronaviruses

R Giri, T Bhardwaj, M Shegane, BR Gehi… - Cellular and Molecular …, 2021 - Springer
The recently emerged coronavirus designated as SARS-CoV-2 (also known as 2019 novel
coronavirus (2019-nCoV) or Wuhan coronavirus) is a causative agent of coronavirus …