[HTML][HTML] Universal irradiation of platelets: Does irradiation affect the quality, effectiveness, and safety of platelets for transfusion?

L Cain, LJ Geneen, M Wiltshire, C Kimber… - Transfusion Medicine …, 2024 - Elsevier
We aimed to identify any detrimental effects on platelet quality and clinical effectiveness, of
irradiated platelets compared to non-irradiated platelets for transfusion. The review was …

Irradiation of platelets in transfusion medicine: risk and benefit judgments

E Hosseini, F Kianinodeh, M Ghasemzadeh - Platelets, 2022 - Taylor & Francis
Irradiation of platelet products is generally used to prevent transfusion-associated graft-
versus-host disease (TA-GvHD) as well as transfusion-transmitted infections. As an essential …

Assessment of the soluble proteins HMGB1, CD40L and CD62P during various platelet preparation processes and the storage of platelet concentrates: The BEST …

F Cognasse, H Hamzeh Cognasse, MA Eyraud… - …, 2023 - Wiley Online Library
Background Structural and biochemical changes in stored platelets are influenced by
collection and processing methods. This international study investigates the effects of …

Gamma irradiation induces a pro-apoptotic state in longer stored platelets, without progressing to an overt apoptosis by day 7 of storage

E Hosseini, FK Nodeh, M Ghasemzadeh - Apoptosis, 2023 - Springer
Background: Although gamma-irradiation to platelet products is a standard method to
prevent the risk of TA-GVHD in vulnerable recipients, it induces some proteomic and redox …

Designing a linear accelerator-based “X irradiation system” for platelet products: an efficient, safe, accessible and cost-effective alternative for conventional X-or …

J Naghinezhad, E Hosseini, Z Siavashpour… - Scientific Reports, 2024 - nature.com
X-irradiation of blood products is an alternative for gamma-ray to prevent post-transfusion
GvHD. However, commercial X-irradiators are not widely available while little is known …

Gamma and X‐ray irradiation do not affect the in vitro quality of refrigerated apheresis platelets in platelet additive solution (PAS‐E)

L Johnson, C Roan, M Costa, HH Aung… - Transfusion, 2022 - Wiley Online Library
Background Platelet refrigeration (cold storage) provides the advantages of an extended
shelf life and reduces the risk of bacterial growth, compared to platelets stored at room …

Effects of radiation exposure and storage on the energy metabolome of platelets in whole blood

SC Becerra, BA Christy, MC Herzig, JA Bynum… - …, 2023 - Wiley Online Library
Background Exposure to radiation through battlefield use of nuclear weapons, terrorist
attacks or accidents at nuclear power plants is a current concern for the military. Beyond the …

X‐ray irradiation effectively inactivated lymphocytes in transfusion in vivo monitored by the bioluminescence transfusion‐associated graft‐versus‐host disease model

D Peng, W Bai, C Zhang, X Chang, P Ma… - Vox …, 2024 - Wiley Online Library
Abstract Background and Objectives Transfusion of cold‐stored whole blood is the preferred
resuscitation method for trauma patients but may cause transfusion‐associated graft‐versus …

X-rays Stimulate Granular Secretions and Activate Protein Kinase C Signaling in Human Platelets

MS Khan, C Liu, F Meng, M Yang, K Zhou… - Current Issues in …, 2023 - mdpi.com
X-rays can induce morphological as well as functional changes in cells. Platelets are
anuclear cellular fragments originating from megakaryocytes and are the major regulators in …