Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …

Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

Prolonged obstruction of the ureter, which leads to injury of the kidney collecting ducts,
results in permanent structural damage, while early reversal allows for repair. Cell structure …

Cells encounter countless external cues and the specificity of their responses is translated
through a myriad of tightly regulated intracellular signals. For this, Rho GTPases play a …

Nephrotic syndrome is a kidney disease featured by heavy proteinuria. It is caused by injury
to the specialized epithelial cells called “podocytes” within the filtration unit of the kidney …

Idiopathic nephrotic syndrome (INS) is a disease involving injury to podocytes in the
glomerular filtration barrier, and its specific causes have not been elucidated. Transfer RNA …

Purpose This study aimed to ascertain the causal association between Ras-related C3
botulinum toxin substrate 1 (RAC1) and the incidence and progression of diabetic kidney …

Abstract Objectives The small GTPase Rac1 (RAC1) has been linked to podocyte disorders
and steroid-sensitive nephrotic syndrome (SSNS). The aim of this study was to explore and …

Selective modulation of Rho GTPase activity in podocytes recapitulates characteristic
features of human nephrosis. Using a mouse model, Robins et al. found that high levels of …

Nephrotic syndrome (NS) is a disease characterized by proteinuria and subsequent
hypoalbuminemia, hyperlipidemia and edema due to the defective renal glomerular filtration …