Gene therapy is poised to revolutionize modern medicine, with seemingly unlimited potential
for treating and curing genetic disorders. For otherwise incurable indications, including most …

The hierarchical three-dimensional folding of the mammalian genome constitutes an
important regulatory layer of gene expression and cell fate control during processes such as …

The transcription factor vitamin D receptor (VDR) is the high affinity nuclear target of the
biologically active form of vitamin D3 (1, 25 (OH) 2D3). In order to identify pure genomic …

Genome sequencing has revealed over 300 million genetic variations in human
populations. Over 90% of variants are single nucleotide polymorphisms (SNPs), the …

Epigenetics studies inheritable and reversible modifications of DNA that allow cells to
control gene expression throughout their development and in response to environmental …

Bone acts as a self-healing organ, which undergoes continuous regeneration process that is
tightly regulated by the cooperation of osteoclasts with the capability of bone resorption and …

A current challenge in genomics is to interpret non-coding regions and their role in
transcriptional regulation of possibly distant target genes. Genome-wide association studies …

The ChIP-seq signal of histone modifications at promoters is a good predictor of gene
expression in different cellular contexts, but whether this is also true at enhancers is not …

Motivation Identifying regulatory regions in the genome is of great interest for understanding
the epigenomic landscape in cells. One fundamental challenge in this context is to find the …

Background Diseases are complex phenotypes often arising as an emergent property of a
non-linear network of genetic and epigenetic interactions. To translate this resulting state …