[HTML][HTML] Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer
Y Tan, R Sun, L Liu, D Yang, Q Xiang, L Li, J Tang… - Theranostics, 2021 - ncbi.nlm.nih.gov
Abstract Rationale: Breast cancer (BrCa) is the most common cancer worldwide, and the 5-
year relative survival rate has declined in patients diagnosed at stage IV. Advanced BrCa is …
year relative survival rate has declined in patients diagnosed at stage IV. Advanced BrCa is …
Transcription factor Zbtb20 as a Regulator of Malignancy and its practical applications
Zbtb20 (zinc finger and BTB domain-containing protein 20) is a transcription factor with a
zinc finger DNA binding domain and a BTB domain responsible for protein–protein …
zinc finger DNA binding domain and a BTB domain responsible for protein–protein …
[HTML][HTML] DNA methylation downregulated ZDHHC1 suppresses tumor growth by altering cellular metabolism and inducing oxidative/ER stress-mediated apoptosis and …
X Le, J Mu, W Peng, J Tang, Q Xiang, S Tian, Y Feng… - Theranostics, 2020 - ncbi.nlm.nih.gov
Cancer progression is an intricate biological process profiled by not only unscheduled
proliferation, but also altered metabolism mechanisms. In this article, we introduced a novel …
proliferation, but also altered metabolism mechanisms. In this article, we introduced a novel …
Landscape and significance of human super enhancer-driven core transcription regulatory circuitry
C Feng, C Song, Y Jiang, J Zhao, J Zhang… - … Therapy-Nucleic Acids, 2023 - cell.com
A core transcription regulatory circuitry (CRC) is an interconnected self-regulatory circuitry
that is formed by a group of core transcription factors (TFs). These core TFs collectively …
that is formed by a group of core transcription factors (TFs). These core TFs collectively …
[HTML][HTML] ZDHHC22-mediated mTOR palmitoylation restrains breast cancer growth and endocrine therapy resistance
J Huang, J Li, J Tang, Y Wu, F Dai, Z Yi… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Palmitoylation is essential for the classic hallmarks of cancers through regulating protein
stability and protein-protein interactions. ZDHHC22, as a well-known member of …
stability and protein-protein interactions. ZDHHC22, as a well-known member of …
BTB/POZ zinc finger protein ZBTB16 inhibits breast cancer proliferation and metastasis through upregulating ZBTB28 and antagonizing BCL6/ZBTB27
J He, M Wu, L Xiong, Y Gong, R Yu, W Peng, L Li… - Clinical …, 2020 - Springer
Background Breast cancer remains in urgent need of reliable diagnostic and prognostic
markers. Zinc finger and BTB/POZ domain-containing family proteins (ZBTBs) are important …
markers. Zinc finger and BTB/POZ domain-containing family proteins (ZBTBs) are important …
ZBTB28 inhibits breast cancer by activating IFNAR and dual blocking CD24 and CD47 to enhance macrophages phagocytosis
L Li, Y Gong, J Tang, C Yan, L Li, W Peng… - Cellular and Molecular …, 2022 - Springer
Breast cancer is the leading cause of cancer death in female. Until now, advanced breast
cancer is still lack effective treatment strategies and reliable prognostic markers. In the …
cancer is still lack effective treatment strategies and reliable prognostic markers. In the …
Cancer cells escape p53's tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation
J Tang, W Peng, Y Feng, X Le, K Wang, Q Xiang, L Li… - Oncogene, 2021 - nature.com
The inactivation of tumor-suppressor genes contributes heavily to oncogenesis. The
mutation of TP53 has been well-studied and recognized as a major factor in the …
mutation of TP53 has been well-studied and recognized as a major factor in the …
ZBTB28 induces autophagy by regulation of FIP200 and Bcl-XL facilitating cervical cancer cell apoptosis
L Li, Y Gong, K Xu, W Chen, J Xia, Z Cheng, L Li… - Journal of Experimental …, 2021 - Springer
Background Among the common preventable cancers of women, cervical cancer has the
highest morbidity. It is curable if detected at an early stage. However, reliable diagnostic and …
highest morbidity. It is curable if detected at an early stage. However, reliable diagnostic and …
Molecular response uncovers neurotoxicity of Pardosa pseudoannulata exposed to cadmium pressure
B Lv, J Wang, Y He, Z Zeng, Y Tang, N Li, L Chen… - Environmental …, 2021 - Elsevier
Cadmium (Cd) is a widely distributed heavy metal in south of China. Growing evidence
indicates that systemic exposure to Cd, particularly the long-term exposure, may cause …
indicates that systemic exposure to Cd, particularly the long-term exposure, may cause …