Review on Alzheimer's disease: inhibition of amyloid beta and tau tangle formation

H Ashrafian, EH Zadeh, RH Khan - International journal of biological …, 2021 - Elsevier
It is reported that approximately 40 million people are suffering from dementia, globally.
Dementia is a group of symptoms that affect neurons and cause some mental disorders …

The role of reactive oxygen species in the pathogenesis of Alzheimer's disease, Parkinson's disease, and Huntington's disease: a mini review

S Manoharan, GJ Guillemin… - Oxidative medicine …, 2016 - Wiley Online Library
Neurodegenerative diseases affect not only the life quality of aging populations, but also
their life spans. All forms of neurodegenerative diseases have a massive impact on the …

Alpha-synuclein oligomers: a new hope

N Bengoa-Vergniory, RF Roberts, R Wade-Martins… - Acta …, 2017 - Springer
Alpha-synuclein is a protein implicated in Parkinson's disease and thought to be one of the
main pathological drivers in the disease, although it remains unclear how this protein elicits …

Biological metals and metal-targeting compounds in major neurodegenerative diseases

KJ Barnham, AI Bush - Chemical Society Reviews, 2014 - pubs.rsc.org
Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …

An integrative approach to ortholog prediction for disease-focused and other functional studies

Y Hu, I Flockhart, A Vinayagam, C Bergwitz, B Berger… - BMC …, 2011 - Springer
Background Mapping of orthologous genes among species serves an important role in
functional genomics by allowing researchers to develop hypotheses about gene function in …

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

J Bieschke, J Russ, RP Friedrich… - Proceedings of the …, 2010 - National Acad Sciences
Protein misfolding and formation of β-sheet-rich amyloid fibrils or aggregates is related to
cellular toxicity and decay in various human disorders including Alzheimer's and Parkinson's …

Molecular mechanisms and potential therapeutical targets in Huntington's disease

C Zuccato, M Valenza, E Cattaneo - Physiological reviews, 2010 - journals.physiology.org
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

DE Ehrnhoefer, J Bieschke, A Boeddrich… - Nature structural & …, 2008 - nature.com
The accumulation of β-sheet–rich amyloid fibrils or aggregates is a complex, multistep
process that is associated with cellular toxicity in a number of human protein misfolding …

Toward the molecular mechanism (s) by which EGCG treatment remodels mature amyloid fibrils

FL Palhano, J Lee, NP Grimster… - Journal of the American …, 2013 - ACS Publications
Protein misfolding and/or aggregation has been implicated as the cause of several human
diseases, such as Alzheimer's and Parkinson's diseases and familial amyloid …

Nutraceutical antioxidants as novel neuroprotective agents

NA Kelsey, HM Wilkins, DA Linseman - Molecules, 2010 - mdpi.com
A variety of antioxidant compounds derived from natural products (nutraceuticals) have
demonstrated neuroprotective activity in either in vitro or in vivo models of neuronal cell …