Background Nestin has been revealed to promote tumorigenesis, progression, metastasis,
and angiogenesis of breast cancer. Although the prognostic and clinicopathological impact …

Background Gliomas are the most common and malignant brain tumors. The standard
therapy is surgery combined with radiotherapy, chemotherapy, and/or other comprehensive …

Preclinical studies suggest that some effects of conventional chemotherapy, and in
particular, gemcitabine, are mediated through enhanced antitumor immune responses. The …

Purpose: Accurate IHC biomarkers incorporating nestin positivity or inositol polyphosphate-4-
phosphate (INPP4B) loss have recently been optimized to identify the basal-like intrinsic …

Breast cancer is one of the leading threats to the health of women. It has the highest
incidence and mortality in women worldwide. Although progress has been made in the …

Both triple negative breast cancer (TNBA) and HER2-positive breast cancer lack expression
of estrogen receptor alpha (ER) and progesterone receptor (PR), while human epidermal …

The development of drug resistance to chemotherapeutic agents has consistently presented
a challenge in terms of the treatment of patients with triple‑negative breast cancer (TNBC). In …

Background Many scientific papers are published each year and substantial resources are
spent to develop biomarker-based tests for precision oncology. However, only a handful of …

Immunotherapy is dramatically changing the landscape of cancer treatment and is becoming
incorporated into the standard of care for some tumor types. Until recently, breast cancer has …

Pancreatic cancer is one of the deadliest malignancies, with 5-year survival rates of less
than 5%. Survival analyses of pancreatic cancer patient databases revealed that high …