Paternal age at conception has been increasing. In this review, we first present the results
from the major mammalian animal models used to establish that increasing paternal age …

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide and
is a significant burden on healthcare systems. α-klotho (klotho) is a protein known for its anti …

The hormonal vitamin D metabolite, 1, 25‐dihydroxyvitamin D [1, 25 (OH) 2D], produced in
kidney, acts in numerous end organs via the nuclear vitamin D receptor (VDR) to trigger …

Infertile men have few treatment options. Here, we demonstrate that the transmembrane
receptor activator of NF-kB ligand (RANKL) signaling system is active in mouse and human …

In comparison to the regulation of calcium homeostasis, which has been widely studied over
the last several decades, phosphate homeostasis is little understood. The parathyroid …

Background Klotho is a pleotropic hormone involved in a multitude of biological processes
necessary for healthy aging, and affords protection from adverse events such as …

Traditional Chinese medicine (TCM) and Western Medicine both have shown efficacy in
treating male sexual dysfunction (MSD). The aim of this perspective paper is to discuss a …

STUDY QUESTION Is serum phosphate linked with semen quality and reproductive
hormones in infertile men? SUMMARY ANSWER Hypophosphatemia is a frequent finding in …

Oxidative stress is the etiology for 30–80% of male patients affected by infertility, which is a
major health problem worldwide. Klotho protein is an aging suppressor that functions as a …

Objective The aim of this systematic review is to provide the first comprehensive overview of
the current knowledge regarding the role of the alpha klotho protein in male and female …