Review and consensus on pharmacogenomic testing in psychiatry

CA Bousman, SA Bengesser, KJ Aitchison… - …, 2021 - thieme-connect.com
The implementation of pharmacogenomic (PGx) testing in psychiatry remains modest, in part
due to divergent perceptions of the quality and completeness of the evidence base and …

A Comprehensive Review of HLA and Severe Cutaneous Adverse Drug Reactions: Implication for Clinical Pharmacogenomics and Precision Medicine

C Kloypan, N Koomdee, P Satapornpong, T Tempark… - Pharmaceuticals, 2021 - mdpi.com
Human leukocyte antigen (HLA) encoded by the HLA gene is an important modulator for
immune responses and drug hypersensitivity reactions as well. Genetic polymorphisms of …

T-CoV: a comprehensive portal of HLA-peptide interactions affected by SARS-CoV-2 mutations

S Nersisyan, A Zhiyanov, M Shkurnikov… - Nucleic acids …, 2022 - academic.oup.com
Rapidly appearing SARS-CoV-2 mutations can affect T cell epitopes, which can help the
virus to evade either CD8 or CD4 T-cell responses. We developed T-cell COVID-19 Atlas (T …

Pharmacogenetics and precision medicine approaches for the improvement of COVID-19 therapies

M Biswas, N Sawajan, T Rungrotmongkol… - Frontiers in …, 2022 - frontiersin.org
Many drugs are being administered to tackle coronavirus disease 2019 (COVID-19)
pandemic situations without establishing clinical effectiveness or tailoring safety. A …

HLA-B*13 :01 Is a Predictive Marker of Dapsone-Induced Severe Cutaneous Adverse Reactions in Thai Patients

P Satapornpong, J Pratoomwun, P Rerknimitr… - Frontiers in …, 2021 - frontiersin.org
HLA-B* 13: 01 allele has been identified as the genetic determinant of dapsone
hypersensitivity syndrome (DHS) among leprosy and non-leprosy patients in several …

Association between HLA alleles and beta-lactam antibiotics-related severe cutaneous adverse reactions

P Wattanachai, W Amornpinyo, P Konyoung… - Frontiers in …, 2023 - frontiersin.org
Introduction: Beta-lactam antibiotics are one of the most common causes of antibiotics-
related severe cutaneous adverse reactions (SCARs) including Stevens–Johnson syndrome …

Spectrum of cutaneous adverse reactions to aromatic antiepileptic drugs and human leukocyte antigen genotypes in Thai patients and meta-analysis

C Sukasem, S Sririttha, C Chaichan, T Nakkrut… - The …, 2021 - nature.com
Aromatic antiepileptic drugs (AEDs)-induced cutaneous adverse drug reactions (cADRs)
add up to the limited use of the AEDs in the treatment and prevention of seizures. Human …

Genetic association of co‐trimoxazole‐induced severe cutaneous adverse reactions is phenotype‐specific: HLA class I genotypes and haplotypes

C Sukasem, J Pratoomwun… - Clinical …, 2020 - Wiley Online Library
Co‐trimoxazole (CTX) causes various forms of severe cutaneous adverse reactions
(SCARs). This case‐control study was conducted to investigate the involvement between …

[HTML][HTML] Enhancing cholangiocarcinoma immunotherapy with adoptive T cells targeting HLA-restricted neoantigen peptides derived from driver gene mutations

A Panya, C Thepmalee, N Sawasdee… - Biomedicine & …, 2023 - Elsevier
Precision immunotherapy, driven by genomic and bioinformatic advancements, has
emerged as a promising and viable approach to combat cancer. Targeting neoantigens …

Associations of HLA and drug-metabolizing enzyme genes in co-trimoxazole-induced severe cutaneous adverse reactions

N Nakkam, N Saksit, P Konyoung… - Drug Metabolism and …, 2022 - Elsevier
Co-trimoxazole is mainly used as a first-line drug for treatment and prophylaxis against
Pneumocystis jiroveci pneumonia. This drug, however, has been reported as the most …