Reactive oxygen species are a constant threat to DNA as they modify bases with the risk of
disrupting genome function, inducing genome instability and mutation. Such risks are due to …

The chemically simple, biologically complex eukaryotic polyamines, spermidine and
spermine, are positively charged alkylamines involved in many crucial cellular processes …

Background DNA is subject to constant chemical modification and damage, which
eventually results in variable mutation rates throughout the genome. Although detailed …

Brain-derived neurotrophic factor (BDNF) has a crucial role in modulating neural and
behavioral plasticity to drugs of abuse. We found a persistent downregulation of exon …

Aging induces myriad cellular and, ultimately, physiological changes that cause a decline in
an organism's functional capabilities. Although the aging process and the pathways that …

DNA damage can significantly modulate expression of the affected genes either by direct
structural interference with transcription components or as a collateral outcome of cellular …

Accumulation of DNA damage resulting from reactive oxygen species was proposed to
cause neurological and degenerative disease in patients, deficient in nucleotide excision …

The common DNA base modification 8-oxo-7, 8-dihydroguanine (8-oxo-G) affects the
efficiency and fidelity of transcription. We constructed plasmid substrates carrying single 8 …

Background Autosomal-dominant polycystic kidney disease (ADPKD) is the leading
inherited renal disease worldwide. The proproliferative function of macrophages is …

Why does a constant barrage of DNA damage lead to disease in some individuals, while
others remain healthy? This article surveys current work addressing the implications of inter …