T cell receptor αβ diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infection
GC Wang, P Dash, JA McCullers, PC Doherty… - Science translational …, 2012 - science.org
A diverse T cell receptor (TCR) repertoire capable of recognizing a broad range of antigenic
peptides is thought to be central to effective pathogen-specific immunity by counteracting …
peptides is thought to be central to effective pathogen-specific immunity by counteracting …
T-cell receptor bias and immunity
S Gras, L Kjer-Nielsen, SR Burrows… - Current opinion in …, 2008 - Elsevier
Despite the potentially vast T-cell repertoire, biased αβ T-cell receptor (TCR) usage has
emerged as a common theme in immunity. Examples of TCR bias are observed in classical …
emerged as a common theme in immunity. Examples of TCR bias are observed in classical …
Killer T cells in influenza
Antigen-specific CD8+ T cells play an important role in virus clearance. Here we review the
current understanding of influenza virus-specific CD8+ T cell immunity in experimental …
current understanding of influenza virus-specific CD8+ T cell immunity in experimental …
A role for differential variable gene pairing in creating T cell receptors specific for unique major histocompatibility ligands
BD Stadinski, P Trenh, RL Smith, B Bautista… - Immunity, 2011 - cell.com
A limited set of T cell receptor (TCR) variable (V) gene segments are used to create a
repertoire of TCRs that recognize all major histocompatibility complex (MHC) ligands within …
repertoire of TCRs that recognize all major histocompatibility complex (MHC) ligands within …
Protective Efficacy of Cross-Reactive CD8+ T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation …
SA Valkenburg, S Gras, C Guillonneau… - PLoS …, 2010 - journals.plos.org
Emergence of a new influenza strain leads to a rapid global spread of the virus due to
minimal antibody immunity. Pre-existing CD8+ T-cell immunity directed towards conserved …
minimal antibody immunity. Pre-existing CD8+ T-cell immunity directed towards conserved …
Paired TCRαβ analysis of virus‐specific CD8+ T cells exposes diversity in a previously defined 'narrow' repertoire
T Cukalac, WT Kan, P Dash, J Guan… - Immunology and cell …, 2015 - Wiley Online Library
T‐cell receptor (TCR) usage has an important role in determining the outcome of CD8+
cytotoxic T‐lymphocyte responses to viruses and other pathogens. However, the …
cytotoxic T‐lymphocyte responses to viruses and other pathogens. However, the …
Ecological analysis of antigen-specific CTL repertoires defines the relationship between naive and immune T-cell populations
Ecology is typically thought of as the study of interactions organisms have with each other
and their environment and is focused on the distribution and abundance of organisms both …
and their environment and is focused on the distribution and abundance of organisms both …
TCR‐pMHC encounter differentially regulates transcriptomes of tissue‐resident CD8 T cells
To investigate the role of TCR‐pMHC interaction in regulating lung CD8 tissue‐resident T
cell (TR) differentiation, polyclonal responses were compared against NP366‐374/Db and …
cell (TR) differentiation, polyclonal responses were compared against NP366‐374/Db and …
Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses
EB Day, C Guillonneau, S Gras… - Proceedings of the …, 2011 - National Acad Sciences
Pathogen-specific responses are characterized by preferred profiles of peptide+ class I MHC
(pMHCI) glycoprotein-specific T-cell receptor (TCR) Variable (V)-region use. How TCRV …
(pMHCI) glycoprotein-specific T-cell receptor (TCR) Variable (V)-region use. How TCRV …
Distinct sets of αβ TCRs confer similar recognition of tumor antigen NY-ESO-1157–165 by interacting with its central Met/Trp residues
L Derré, M Bruyninx, P Baumgaertner… - Proceedings of the …, 2008 - National Acad Sciences
Naturally acquired immune responses against human cancers often include CD8+ T cells
specific for the cancer testis antigen NY-ESO-1. Here, we studied T cell receptor (TCR) …
specific for the cancer testis antigen NY-ESO-1. Here, we studied T cell receptor (TCR) …