The absorption of orally administered drug products is a complex, dynamic process,
dependant on a range of biopharmaceutical properties; notably the aqueous solubility of a …

The Caco-2 cellular monolayer is a widely accepted in vitro model to predict human
permeability but suffering from several and critical limitations. Therefore, some alternative …

Nanotechnology utilises particles of between 1 and 100 nm in size. In recent years, it has
enjoyed widespread application in a variety of areas. However, this has also raised …

Biopharmaceutical classification system (BCS) class IV drugs (low-solubility low-
permeability) are generally poor drug candidates, yet,~ 5% of oral drugs on the market …

Hydrogels are widely studied as drug delivery system. In this work we propose the
employment of tetrakis (hydroxymethyl) phosphonium chloride as crosslinking agent to …

Microcontainers with an inner diameter of 223 μm are fabricated using the polymer SU-8,
and evaluated in vitro, in situ and in vivo for their application as an advanced oral drug …

Drug development is an ever-growing field, increasingly requesting reliable in vitro tools to
speed up early screening phases, reducing the need for animal experiments. In oral …

Our aim is to develop and to validate the in situ closed loop perfusion method in rat colon
and to compare with small intestine and Caco-2 cell models. Correlations with human oral …

Rifaximin is a BCS class IV (low-solubility, low-permeability) drug and also a P-gp substrate.
The aims of this work were to assess the efficiency of different rifaximin amorphous solid …

Models intended to predict intestinal absorption are an essential part of the drug
development process. Although many models exist for capturing intestinal absorption, many …