Publisher Summary The chapter introduces the mitogen-activated protein (MAP) kinase
(MAPK) module. The identification of MAP kinase pathways exemplifies the power of …

Platelet-derived growth factor (PDGF) exerts its stimulatory effects on cell growth and motility
by binding to two related protein tyrosine kinase receptors. Ligand binding induces receptor …

Neurotrophins regulate neuronal survival, differentiation, and synaptic function. To
understand how neurotrophins elicit such diverse responses, we elucidated signaling …

MAP kinases help to mediate diverse processes ranging from transcription of
protooncogenes to programmed cell death. More than a dozen mammalian MAP kinase …

Integrins mediate cell adhesion, migration, and a variety of signal transduction events.
These integrin actions can overlap or even synergize with those of growth factors. We …

The neurotrophins signal cell survival, differentiation, growth cessation, and apoptosis
through two cell surface receptors, the Trks and p75NTR (p75 neurotrophin receptor) …

Here, we identify a mouse homolog of the Drosophila Disabled (Dab) protein, mDab1, and
show it is an adaptor molecule functioning in neural development. We find that mDab1 is …

MKP-1 (also known as CL100, 3CH134, Erp, and hVH-1) exemplifies a class of dual-
specificity phosphatase able to reverse the activation of mitogen-activated protein (MAP) …

Background: Mitogen-activated protein (MAP) kinases are ubiquitous components of many
signal transduction pathways. Constitutively active variants have been isolated for every …

The platelet-derived growth factor β receptor (PDGFRβ) is known to activate many
molecules involved in signal transduction and has been a paradigm for receptor tyrosine …