The challenges of primary biliary cholangitis: What is new and what needs to be done

BT Beretta-Piccoli, G Mieli-Vergani, D Vergani… - Journal of …, 2019 - Elsevier
Abstract Primary Biliary Cholangitis (PBC) is an uncommon, chronic, cholangiopathy of
autoimmune origin and unknown etiology characterized by positive anti-mitochondrial …

Pharmacological interventions for primary biliary cholangitis

F Saffioti, KS Gurusamy, LH Eusebi… - Cochrane Database …, 2017 - cochranelibrary.com
Background Primary biliary cholangitis (previously primary biliary cirrhosis) is a chronic liver
disease caused by the destruction of small intra‐hepatic bile ducts resulting in stasis of bile …

Protective effect and mechanism of placenta extract on liver

LH Shen, L Fan, Y Zhang, YK Zhu, XL Zong, GN Peng… - Nutrients, 2022 - mdpi.com
The placenta contains multiple biologically active substances, which exert antioxidation, anti-
inflammatory, immunomodulatory, and delayed aging effects. Its extract can improve hepatic …

Old and new treatments for primary biliary cholangitis

D Chascsa, EJ Carey, KD Lindor - Liver International, 2017 - Wiley Online Library
Primary biliary cholangitis (formerly primary biliary cirrhosis) is a rare progressive cholestatic
liver disease, whose hallmark features include a persistently elevated alkaline phosphatase …

Creation of a long-acting nanoformulated 2′, 3′-dideoxy-3′-thiacytidine

D Guo, T Zhou, M Araínga, D Palandri… - JAIDS Journal of …, 2017 - journals.lww.com
Background: Antiretroviral drug discovery and formulation design will facilitate viral
clearance in infectious reservoirs. Although progress has been realized for selected …

Is PBC a viral infectious disease?

AL Mason - Best Practice & Research Clinical Gastroenterology, 2018 - Elsevier
The human betaretrovirus and the closely related mouse mammary tumor virus have been
linked with the development of cholangitis and mitochondrial antibody production in patients …

High occurrence of small intestinal bacterial overgrowth in primary biliary cholangitis

J Liu Chen Kiow, C Vincent, S Sidani… - …, 2019 - Wiley Online Library
Background Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease
affecting mainly middle‐aged women. An alteration in intestinal motility has been well …

Randomized clinical trial: Combination antiretroviral therapy with tenofovir-emtricitabine and lopinavir-ritonavir in patients with primary biliary cholangitis

E Lytvyak, I Hosamani… - Canadian liver …, 2019 - canlivj.utpjournals.press
Background: Prior studies using reverse transcriptase inhibitors to treat a human
betaretrovirus (HBRV) in patients with primary biliary cholangitis (PBC) resulted in a 21 …

Combination antiretroviral therapy improves recurrent primary biliary cholangitis following liver transplantation

E Lytvyak, M Niazi, R Pai, D He, G Zhang… - Liver …, 2021 - Wiley Online Library
Recurrent primary biliary cholangitis (rPBC) is frequent following liver transplantation and
associated with increased morbidity and mortality. It has been argued that rPBC behaves …

Isolation of a human betaretrovirus from patients with primary biliary cholangitis

M Goubran, W Wang, S Indik, A Faschinger… - Viruses, 2022 - mdpi.com
A human betaretrovirus (HBRV) has been linked with the autoimmune liver disease, primary
biliary cholangitis (PBC), and various cancers, including breast cancer and lymphoma …