In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …

Non-human animals represent a large and important feature in the history of biomedical
research. The validity of their use, in terms of reproducible outcomes and translational …

Background Fetal inflammatory response mediated by the influx of immune cells and
activation of pro-inflammatory transcription factor NF-κB in feto-maternal uterine tissues is …

Genital mycoplasmas can break the cervical barrier and cause intraamniotic infection and
preterm birth. This study developed a six-chamber vagina-cervix-decidua-organ-on-a-chip …

Preterm birth, the leading cause of perinatal morbidity, often follows premature labor, a
syndrome whose prevention remains a challenge. To better understand the relationship …

This study determined if exosomes from ectocervical epithelial (ECTO) cells infected with
Ureaplasma parvum (U. parvum) can carry bacterial antigens and cause inflammation at the …

Context Cervical excision is a risk factor for preterm birth. This suggests that the cervix plays
an essential role in the maintenance of pregnancy. Objective We investigated the role of the …

Oxidative stress (OS) and inflammation arising from cellular derangements at the fetal
membrane‐decidual interface (feto‐maternal interface [FMi]) is a major antecedent to …

Mice are frequently used as animal models for mechanistic studies of infection and
obstetrical disease, yet characterization of the murine microbiota during pregnancy is …

Introduction: During pregnancy, fetal cells can be incorporated into maternal tissues (fetal
microchimerism), where they can persist postpartum. Whether these fetal cells are beneficial …