Emerging drug targets for endometriosis

MM Dolmans, J Donnez - Biomolecules, 2022 - mdpi.com
Endometriosis is a chronic inflammatory disease causing distressing symptoms and
requiring a life-long management strategy. The objective of this review is to evaluate …

Peritoneal fluid progesterone and progesterone resistance in superficial endometriosis lesions

PR Koninckx, A Ussia, L Adamyan, V Gomel… - Human …, 2022 - academic.oup.com
Peritoneal fluid in ovulatory women is an ovarian exudate with higher estrogen and
progesterone concentrations than in plasma. In the follicular phase, progesterone …

New concepts on the etiology of endometriosis

FL Cousins, BD McKinnon, S Mortlock… - Journal of Obstetrics …, 2023 - Wiley Online Library
Endometriosis is a serious, chronic disorder where endometrial tissue grows outside the
uterus, causing severe pelvic pain and infertility. It affects 11% of women. Endometriosis is a …

Gene expression profiles separate endometriosis lesion subtypes and indicate a sensitivity of endometrioma to estrogen suppressive treatments through elevated …

S Marla, S Mortlock, T Heinosalo, M Poutanen… - BMC medicine, 2023 - Springer
Background Endometriosis is a common, gynaecological disease characterised by the
presence of endometrial-like cells growing outside the uterus. Lesions appear at multiple …

Peripheral, central, and cross sensitization in endometriosis-associated pain and comorbid pain syndromes

HC McNamara, HC Frawley, JF Donoghue… - … in Reproductive Health, 2021 - frontiersin.org
Endometriosis-associated pain and the mechanisms responsible for its initiation and
persistence are complex and difficult to treat. Endometriosis-associated pain is experienced …

Superficial Endometriosis at Ultrasound Examination—A Diagnostic Criteria Proposal

M Pedrassani, S Guerriero, MÁ Pascual, S Ajossa… - Diagnostics, 2023 - mdpi.com
The actual prevalence of superficial endometriosis is not known. However, it is considered
the most common subtype of endometriosis. The diagnosis of superficial endometriosis …

Menstruation dysregulation and endometriosis development

KKW Kuan, DA Gibson, LHR Whitaker… - … in Reproductive Health, 2021 - frontiersin.org
Endometriosis is a common gynecological condition characterized by the growth of
endometrial-like tissue outside of the uterus which may cause symptoms such as chronic …

Is there a role for small molecule metabolite biomarkers in the development of a diagnostic test for endometriosis?

NE Tomkins, JE Girling, B Boughton… - Systems Biology in …, 2022 - Taylor & Francis
Endometriosis is a disease defined by the presence of benign lesions of endometrial-like
glands and stroma outside the endometrial cavity. Affecting an estimated 11.4% of …

Is intracrinology of endometriosis relevant in clinical practice? A systematic review on estrogen metabolism

A Mercorio, P Giampaolino, A Romano… - Frontiers in …, 2022 - frontiersin.org
Endometriosis is a chronic, multifactorial, estrogen-dependent disease. The abnormal
endocrine microenvironment of endometriosis lesions is considered a main feature and …

Decidualization of endometriosis in a cohort of IVF-mediated pregnancies

F Filippi, L Benaglia, F Alagna, I La Vecchia… - Scientific Reports, 2022 - nature.com
Decidualization is the process of endometrial change in pregnancy, a phenomenon that can
involve also ovarian endometriomas. However, the frequency of this event remains …