Animal models of exercise from rodents to pythons

MH Hastings, JJ Herrera, JS Guseh, B Atlason… - Circulation …, 2022 - Am Heart Assoc
Acute and chronic animal models of exercise are commonly used in research. Acute
exercise testing is used, often in combination with genetic, pharmacological, or other …

Cellular mechanisms mediating exercise-induced protection against cardiotoxic anthracycline cancer therapy

S Dozic, EJ Howden, JR Bell, KM Mellor… - Cells, 2023 - mdpi.com
Anthracyclines such as doxorubicin are widely used chemotherapy drugs. A common side
effect of anthracycline therapy is cardiotoxicity, which can compromise heart function and …

[HTML][HTML] Beyond cardiomyocytes: cellular diversity in the heart's response to exercise

LE Trager, M Lyons, A Kuznetsov, C Sheffield… - Journal of Sport and …, 2023 - Elsevier
Abstract Cardiomyocytes comprise∼ 70% to 85% of the total volume of the adult
mammalian heart but only about 25% to 35% of its total number of cells. Advances in single …

Cardiomyocyte atrophy, an underestimated contributor in doxorubicin-induced cardiotoxicity

DS Chen, J Yan, PZ Yang - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Left ventricular (LV) mass loss is prevalent in doxorubicin (DOX)-induced cardiotoxicity and
is responsible for the progressive decline of cardiac function. Comparing with the well …

[HTML][HTML] Exercise in cancer care for people with lung cancer: A narrative synthesis

K Toohey, D Mizrahi, NH Hart, B Singh, P Lopez… - Journal of science and …, 2024 - Elsevier
Objective Lung cancer is the second most common cancer diagnosed worldwide, resulting
in significant physical and psychological consequences. In this narrative review, we explore …

Comparison of three exercise interventions with and without gemcitabine treatment on pancreatic tumor growth in mice: No impact on tumor infiltrating lymphocytes

P Gupta, CF Hodgman, C Alvarez-Florez… - Frontiers in …, 2022 - frontiersin.org
Exercise has been shown to slow pancreatic tumor growth, but whether exercise
interventions of differing volume or intensity yield differential effects on tumor outcomes is …

Does myocardial atrophy represent anti-arrhythmic phenotype?

BS Bacova, K Andelova, M Sykora, T Egan Benova… - Biomedicines, 2022 - mdpi.com
This review focuses on cardiac atrophy resulting from mechanical or metabolic unloading
due to various conditions, describing some mechanisms and discussing possible strategies …

Exercise intensity governs tumor control in mice with breast cancer

IL Gomes-Santos, AS Kumar, F Hausmann… - Frontiers in …, 2024 - frontiersin.org
Introduction Exercise is recommended as an adjunct therapy in cancer, but its effectiveness
varies. Our hypothesis is that the benefit depends on the exercise intensity. Methods We …

Voluntary wheel running reduces tumor growth and increases capillarity in the heart during doxorubicin chemotherapy in a murine model of breast cancer

TM Uurasmaa, C Ricardo, A Autio… - Frontiers in …, 2024 - frontiersin.org
Introduction: The possible beneficial effects of physical activity during doxorubicin treatment
of breast cancer need further investigation as many of the existing studies have been done …

[HTML][HTML] New insights into cardioprotection in breast cancer patients undergoing physical exercise during chemotherapy: A systematic review and meta-analysis

BG Linhares, DG Linhares, G Boppre… - Current Problems in …, 2024 - Elsevier
Background: Chemotherapy associated with breast cancer often induces cardiotoxicity,
which compromises patients' health and quality of life. Objective: To verify the effect of …