Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice

Q Shi, S Chowdhury, R Ma, KX Le, S Hong… - Science translational …, 2017 - science.org
The complement cascade not only is an innate immune response that enables removal of
pathogens but also plays an important role in microglia-mediated synaptic refinement during …

The monkey head mushroom and memory enhancement in Alzheimer's disease

Yanshree, WS Yu, ML Fung, CW Lee, LW Lim… - Cells, 2022 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disorder, and no effective treatments are
available to treat this disorder. Therefore, researchers have been investigating Hericium …

Social defeat models in animal science: What we have learned from rodent models

A Toyoda - Animal Science Journal, 2017 - Wiley Online Library
Studies on stress and its impacts on animals are very important in many fields of science,
including animal science, because various stresses influence animal production and animal …

Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer's disease therapy

Y Zhou, F Zhu, Y Liu, M Zheng, Y Wang, D Zhang… - Science …, 2020 - science.org
Toxic aggregated amyloid-β accumulation is a key pathogenic event in Alzheimer's disease
(AD), which derives from amyloid precursor protein (APP) through sequential cleavage by …

Complement C3-deficient mice fail to display age-related hippocampal decline

Q Shi, KJ Colodner, SB Matousek, K Merry… - Journal of …, 2015 - Soc Neuroscience
The complement system is part of the innate immune response responsible for removing
pathogens and cellular debris, in addition to helping to refine CNS neuronal connections via …

Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress

S Haider, L Liaquat, S Ahmad, Z Batool, RA Siddiqui… - Plos one, 2020 - journals.plos.org
Currently prescribed medications for the treatment of Alzheimer's disease (AD) that are
based on acetylcholinesterase inhibition only offer symptomatic relief but do not provide …

Functionalized nanoparticles for brain targeted BDNF gene therapy to rescue Alzheimer's disease pathology in transgenic mouse model

S Arora, T Kanekiyo, J Singh - International Journal of Biological …, 2022 - Elsevier
Brain-derived neurotrophic factor (BDNF) is actively produced and utilized in cortical circuits
throughout life to sustain neuronal function and synaptic plasticity. In animal models of …

Bifidobacterium Lactis Probio-M8 regulates gut microbiota to alleviate Alzheimer's disease in the APP/PS1 mouse model

J Cao, WK Amakye, C Qi, X Liu, J Ma, J Ren - European Journal of …, 2021 - Springer
Purpose Studies have shown that Alzheimer's disease is associated with significant
alterations in the gut microbiota. But the effect of probiotics and/or prebiotics on Alzheimer's …

Progressive release of mesoporous nano-selenium delivery system for the multi-channel synergistic treatment of Alzheimer's disease

J Sun, C Wei, Y Liu, W Xie, M Xu, H Zhou, J Liu - Biomaterials, 2019 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease with a complex pathogenesis.
Controlled release, target ability, and multi-channel synergistic treatment are key factors …

[HTML][HTML] High fat diet exacerbates Alzheimer's disease-related pathology in APPswe/PS1 mice

P Thériault, A ElAli, S Rivest - Oncotarget, 2016 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is mainly characterized by the accumulation and aggregation of
amyloid-β (Aβ) peptides in brain parenchyma and cerebral microvasculature. Unfortunately …