Antibiotics are often used in human and veterinary medicine for the treatment of bacterial
diseases. However, extensive use of antibiotics in agriculture can result in the contamination …

Aptamers have been widely researched and applied in nanomedicine due to their
programmable, activatable, and switchable properties. However, there are few reviews on …

RNA molecules are becoming an important target class in drug discovery. However, the
principles for designing RNA-binding small molecules are yet to be fully uncovered. In this …

Understanding the 3-D structure of nucleic acid aptamers is important for the rational design
of aptamer-based constructs in various applications, including for developing aptasensors …

Nucleobase π–π stacking is one of the crucial organizing interactions within three-
dimensional (3D) RNA architectures. Characterizing the structural variability of these …

A nonredundant dataset of∼ 300 high (up to 2.5 Å) resolution X‐ray structures of RNA:
protein complexes were analyzed for hydrogen bonds between amino‐acid residues and …

Guanidinium ion is a toxic cellular metabolite. The ykkC-III riboswitch, an mRNA stretch,
regulates the gene expression by undergoing a conformational change in response to the …

The diversity and complexity of RNA include sequence, secondary structure, and tertiary
structure characteristics. These elements are crucial for RNA's specific recognition of other …

The construction of a fluorescence aptamer sensor was achieved by employing the
fundamental principle of fluorescence resonance energy transfer. By employing molecular …

The structure-function relationship of the riboswitch is governed mainly by two factors, ligand
binding and temperature. Most of the experimental studies shed light on structural dynamics …