The Epidemiology and Pathogenesis and Treatment of Pseudomonas aeruginosa Infections: An Update

D Reynolds, M Kollef - Drugs, 2021 - Springer
Pseudomonas aeruginosa is a Gram-negative bacterial pathogen that is a common cause of
nosocomial infections, particularly pneumonia, infection in immunocompromised hosts, and …

Epidemiology, biology, and impact of clonal Pseudomonas aeruginosa infections in cystic fibrosis

MD Parkins, R Somayaji, VJ Waters - Clinical microbiology …, 2018 - Am Soc Microbiol
Chronic lower airway infection with Pseudomonas aeruginosa is a major contributor to
morbidity and mortality in individuals suffering from the genetic disease cystic fibrosis (CF) …

Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist

DP Nichols, SJ Morgan, M Skalland… - The Journal of …, 2023 - Am Soc Clin Investig
Background Lung infections are among the most consequential manifestations of cystic
fibrosis (CF) and are associated with reduced lung function and shortened survival. Drugs …

[HTML][HTML] Treatment of lung infection in patients with cystic fibrosis: current and future strategies

G Döring, P Flume, H Heijerman, JS Elborn… - Journal of Cystic …, 2012 - Elsevier
In patients with cystic fibrosis (CF) lung damage secondary to chronic infection is the main
cause of death. Treatment of lung disease to reduce the impact of infection, inflammation …

Impact of Pseudomonas aeruginosa Infection on Patients with Chronic Inflammatory Airway Diseases

M Garcia-Clemente, D de la Rosa, L Máiz… - Journal of clinical …, 2020 - mdpi.com
Pseudomonas aeruginosa (P. aeruginosa) is a ubiquitous and opportunistic microorganism
and is considered one of the most significant pathogens that produce chronic colonization …

Clinical significance of microbial infection and adaptation in cystic fibrosis

AR Hauser, M Jain, M Bar-Meir… - Clinical microbiology …, 2011 - Am Soc Microbiol
SUMMARY A select group of microorganisms inhabit the airways of individuals with cystic
fibrosis. Once established within the pulmonary environment in these patients, many of …

Pseudomonas aeruginosa Diversification during Infection Development in Cystic Fibrosis Lungs—A Review

AM Sousa, MO Pereira - Pathogens, 2014 - mdpi.com
Pseudomonas aeruginosa is the most prevalent pathogen of cystic fibrosis (CF) lung
disease. Its long persistence in CF airways is associated with sophisticated mechanisms of …

Factors associated with FEV1 decline in cystic fibrosis: analysis of the ECFS patient registry

E Kerem, L Viviani, A Zolin, S MacNeill… - European …, 2013 - publications.ersnet.org
Pulmonary insufficiency is the main cause of death in cystic fibrosis (CF). We analysed
forced expiratory volume in 1 s (FEV1) data of 14 732 patients registered in the European …

Changing epidemiology of the respiratory bacteriology of patients with cystic fibrosis

EL Salsgiver, AK Fink, EA Knapp, JJ LiPuma… - Chest, 2016 - Elsevier
Background Monitoring potential changes in the epidemiology of cystic fibrosis (CF)
pathogens furthers our understanding of the potential impact of interventions. Methods We …

Cystic Fibrosis Foundation Pulmonary Guideline. Pharmacologic Approaches to Prevention and Eradication of Initial Pseudomonas aeruginosa Infection

PJ Mogayzel Jr, ET Naureckas… - Annals of the …, 2014 - atsjournals.org
Description: The Cystic Fibrosis (CF) Foundation developed clinical care guidelines for the
prevention of Pseudomonas aeruginosa infection, the treatment of initial P. aeruginosa …