Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Regular exercise is a formidable regulator of insulin sensitivity and overall systemic
metabolism through both acute events driven by each exercise bout and through chronic …

In vitro models of contractile human skeletal muscle hold promise for use in disease
modeling and drug development, but exhibit immature properties compared to native adult …

The beneficial health‐related effects of exercise are well recognized, and numerous studies
have investigated underlying mechanism using various in vivo and in vitro models. Although …

Exercise is a first-line treatment for type 2 diabetes and preserves β-cell function by hitherto
unknown mechanisms. We postulated that proteins from contracting skeletal muscle may act …

New Findings What is the topic of this review? This review discusses the evidence of the
benefits of exercise training for β‐cell health through improvements in function, proliferation …

Previous studies on the mechanisms of peripheral nerve injury (PNI) have mainly focused
on the pathophysiological changes within a single injury site. However, recent studies have …

New Findings What is the central question of this study? Is electrical pulse stimulation (EPS)
an in vitro exercise model able to elicit the hypertrophy of human muscle cells? What is the …

Exercise provides a cornerstone in the prevention and treatment of several chronic
diseases. The use of in vivo exercise models alone cannot fully establish the skeletal muscle …

Skeletal muscle is an endocrine organ that secretes a variety of compounds including
proteins (myokines), metabolites, microRNAs (miRNAs), and exosomes, many of which are …