In the present scenario, resistance to antibiotics is one of the crucial issues related to public
health. Earlier, such resistance to antibiotics was limited to nosocomial infections, but it has …

The importance of the cell wall to the viability of the bacterium is underscored by the breadth
of antibiotic structures that act by blocking key enzymes that are tasked with cell-wall …

Many Gram‐negative and Gram‐positive bacteria recycle a significant proportion of the
peptidoglycan components of their cell walls during their growth and septation. In many …

In the 80 years since their discovery the β-lactam antibiotics have progressed through
structural generations, each in response to the progressive evolution of bacterial resistance …

The history of modern medicine cannot be written apart from the history of the antibiotics.
Antibiotics are cytotoxic secondary metabolites that are isolated from Nature. The …

In Enterobacteriaceae, the transcriptional regulator AmpR, a member of the LysR family,
regulates the expression of a chromosomal β-lactamase AmpC. The regulatory repertoire of …

Enterobacter cloacae complex (ECC), an opportunistic pathogen causing numerous
infections in hospitalized patients worldwide, is able to resist β-lactams mainly by producing …

The bacterial cell-wall that forms a protective layer over the inner membrane is called the
murein sacculus–a tightly cross-linked peptidoglycan mesh unique to bacteria. Cell-wall …

The peptidoglycan is the structural polymer of the bacterial cell envelope. In contrast to an
expectation of a structural stasis for this polymer, during the growth of the Gram-negative …

This study aimed to characterize the role of Pseudomonas aeruginosa low-molecular-mass
penicillin-binding proteins (LMM PBPs), namely, PBP4 (DacB), PBP5 (DacC), and PBP7 …