Photochromism is defined as a reversible transformation of a chemical species between two
isomers having different absorption spectra induced in one or both directions by …

Abstract Nonconjugated hydrocarbons, like bicyclo [1.1. 1] pentane, bicyclo [2.2. 2] octane,
triptycene, and cubane are a unique class of rigid linkers. Due to their similarity in size and …

Driven by the ever-increasing pace of drug discovery and the need to push the boundaries
of unexplored chemical space, medicinal chemists are routinely turning to unusual strained …

We report a general preparation of arylated bicyclo [1.1. 1] pentanes through the opening of
[1.1. 1] propellane with various arylmagnesium halides. After transmetalation with ZnCl2 and …

Abstract “Escaping from flatland”, by increasing the saturation level and three‐
dimensionality of drug‐like compounds, can enhance their potency, selectivity and …

Propellanes are a unique class of compounds currently consisting of well over 10 000
representatives, all featuring two more or less inverted tetrahedral carbon atoms that are …

Disubstituted bicyclo [1.1. 1] pentanes (BCPs) are valuable bioisosteres of para‐substituted
aromatic rings. The most direct route to these structures is via multicomponent ring‐opening …

Photoswitchable or photoactivatable fluorescent dyes are potentially applicable to ultrahigh
density optical memory media as well as super-resolution fluorescence imaging when the …

The bicyclo [1.1. 1] pentane (BCP) motif has been utilized as bioisosteres in drug candidates
to replace phenyl, tert-butyl, and alkynyl fragments in order to improve physicochemical …

A comprehensive review to the synthesis, properties, and applications of diarylethene-based
molecular photoswitches Diarylethene Molecular Photoswitches: Concept and …