Simple Summary The protein kinase C (PKC) family belongs to serine-threonine kinases
and consists of several subtypes. Increasing evidence suggests that PKCs are critical …

Metastasis is considered as the major cause of cancer death. Cancer cells can be released
from primary tumors into the circulation and then colonize in distant organs. How cancer …

Gene expression signatures associated with breast cancer metastases suggest that
metabolic re-wiring is important for metastatic growth in lungs, bones, and other organs …

Bone marrow is the primary site of blood cell production in adults and serves as the source
of osteoblasts and osteoclasts that maintain bone homeostasis. The medullary …

Cancer dormancy is a phenomenon defined by the entry of cancer cells into a reversible
quiescent, nonproliferative state, and represents an essential part of the metastatic cascade …

Metabolic reprogramming of cancer cells and the tumour microenvironment are pivotal
characteristics of cancers, and studying these processes offer insights and avenues for …

The success of disseminating cancer cells (DTCs) at specific metastatic sites is influenced
by several metabolic factors. Even before DTCs arrival, metabolic conditioning from the …

Abstract Purpose of Review Breast and prostate tumors frequently metastasize to the bone,
but the underlying mechanisms for osteotropism remain elusive. An emerging feature of …

Background: Accumulating evidence indicates that PSAT1 not only reprogrammed
metabolic function but also exhibits “moonlighting” functions in promoting tumor malignancy …

Purpose Esophageal squamous carcinoma (ESCC) with a high incidence in China, lacks
effective therapeutic targets. Phosphoglycerate dehydrogenase (PHGDH) is a key enzyme …