Much evidence shows that physical exercise (PE) is a strong gene modulator that induces
structural and functional changes in the brain, determining enormous benefit on both …

This review provides the reader with the up‐to‐date evidence‐based basis for prescribing
exercise as medicine in the treatment of 26 different diseases: psychiatric diseases …

Sarcopenia is the loss of skeletal muscle mass and function with advancing age. It involves
both complex genetic and modifiable risk factors, such as lack of exercise, malnutrition and …

Abstract “The Scaffolding Theory of Aging and Cognition (STAC)”, proposed in 2009, is a
conceptual model of cognitive aging that integrated evidence from structural and functional …

A large amount of evidence has demonstrated the power of exercise to support cognitive
function, the effects of which can last for considerable time. An emerging line of scientific …

Background Whether hearing loss is independently associated with accelerated cognitive
decline in older adults is unknown. Methods We studied 1984 older adults (mean age, 77.4 …

Background Cognitive impairment, including dementia, is a major health concern with the
increasing aging population. Preventive measures to delay cognitive decline are of utmost …

Background and Purpose—This scientific statement provides an overview of the evidence
on vascular contributions to cognitive impairment and dementia. Vascular contributions to …

The pathophysiological process of Alzheimer's disease (AD) is thought to begin many years
before the diagnosis of AD dementia. This long “preclinical” phase of AD would provide a …

For more than 50 years, psychologists, gerontologists, and, more recently, neuroscientists
have considered the possibility of successful aging. How to define successful aging remains …