The retention of infected cells in a wide variety of tissues, often with distinct viral and cellular
characteristics, underscores the importance of studying tissue reservoirs in the development …

The lentivirus human immunodeficiency virus (HIV) causes AIDS by interacting with a large
number of different cells in the body and escaping the host immune response against it. HIV …

Several members of the chemokine receptor family are used together with CD4 for HIV-1
entry into target cells1–6. T cell line-tropic (T-tropic) HIV-1 viruses use the chemokine …

This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …

Microglia are associated with central nervous system (CNS) pathology of both Alzheimer's
disease (AD) and the acquired immunodeficiency syndrome (AIDS). In AD, microglia …

HIV-1 replication in the central nervous system (CNS) is typically limited by the availability of
target cells. HIV-1 variants that are transmitted and dominate the early stages of infection …

The binding of the human immunodeficiency virus (HIV) envelope glycoprotein gp120 to the
cell surface receptor CD4 has been considered a primary determinant of viral tropism. A …

The availability of highly active antiretroviral therapies (HAART) has not eliminated HIV-1
infection of the central nervous system (CNS) or the occurrence of HIV-associated …

Proinflammatory cytokines, tumour necrosis factor (TNF)-α, interferon (IFN)-γ and interleukin
(IL)-6, have multiple effects in the central nervous system (CNS) not strictly cytotoxic being …

We constructed a recombinant human immunodeficiency virus (HIV) vector to facilitate
studies of virus infectivity. A drug resistance gene was inserted into a gp160-HIV proviral …