[HTML][HTML] Dosing extracellular vesicles

D Gupta, AM Zickler, S El Andaloussi - Advanced drug delivery reviews, 2021 - Elsevier
Extracellular vesicles (EVs) are natural nanoparticles containing biologically active
molecules. They are important mediators of intercellular communication and can be …

Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders

NA Maskalenko, D Zhigarev… - Nature reviews Drug …, 2022 - nature.com
Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and
viral infections. They are 'first responders' that can spontaneously recognize abnormal cells …

Exosome-mediated genetic reprogramming of tumor-associated macrophages by exoASO-STAT6 leads to potent monotherapy antitumor activity

S Kamerkar, C Leng, O Burenkova, SC Jang… - Science …, 2022 - science.org
Effectiveness of checkpoint immunotherapy in cancer can be undermined by
immunosuppressive tumor-associated macrophages (TAMs) with an M2 phenotype …

Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities

B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …

Extracellular vesicles in cancer drug resistance: roles, mechanisms, and implications

Q Yang, J Xu, J Gu, H Shi, J Zhang, J Zhang… - Advanced …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are cell‐derived nanosized vesicles that mediate cell‐to‐cell
communication via transporting bioactive molecules and thus are critically involved in …

[HTML][HTML] New advances in exosome-based targeted drug delivery systems

D Ferreira, JN Moreira, LR Rodrigues - Critical Reviews in Oncology …, 2022 - Elsevier
In recent years, various drug nano-delivery platforms have emerged to enhance drug
effectiveness in cancer treatment. However, their successful translation to clinics have been …

Extracellular vesicles as next generation immunotherapeutics

DW Greening, R Xu, A Ale, CE Hagemeyer… - Seminars in Cancer …, 2023 - Elsevier
Extracellular vesicles (EVs) function as a mode of intercellular communication and
molecular transfer to elicit diverse biological/functional response. Accumulating evidence …

Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification

Q Liu, D Li, X Pan, Y Liang - Journal of nanobiotechnology, 2023 - Springer
Abstract Extracellular vesicles (EVs) are 30–150 nm membrane-bound vesicles naturally
secreted by cells and play important roles in intercellular communication by delivering …

Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy

R Hosseini, H Sarvnaz, M Arabpour, SM Ramshe… - Molecular cancer, 2022 - Springer
Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is
now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity …

The roles of small extracellular vesicles in cancer and immune regulation and translational potential in cancer therapy

K Qian, W Fu, T Li, J Zhao, C Lei, S Hu - Journal of Experimental & Clinical …, 2022 - Springer
Extracellular vesicles (EVs) facilitate the extracellular transfer of proteins, lipids, and nucleic
acids and mediate intercellular communication among multiple cells in the tumour …