Matrine: A review of its pharmacology, pharmacokinetics, toxicity, clinical application and preparation researches

X Li, Z Tang, L Wen, C Jiang, Q Feng - Journal of Ethnopharmacology, 2021 - Elsevier
Ethnopharmacological relevance “Dogel ebs” was known as Sophora flavescens Ait., which
has been widely utilized in the clinical practice of traditional Chinese Mongolian herbal …

A systematic review of the pharmacology, toxicology and pharmacokinetics of matrine

L You, C Yang, Y Du, W Wang, M Sun, J Liu… - Frontiers in …, 2020 - frontiersin.org
Matrine (MT) is a naturally occurring alkaloid and an bioactive component of Chinese herbs,
such as Sophora flavescens and Radix Sophorae tonkinensis. Emerging evidence suggests …

Targeting Keap1/Nrf2/ARE signaling pathway in multiple sclerosis

D Michaličková, T Hrnčíř, NK Canová… - European journal of …, 2020 - Elsevier
Multiple sclerosis (MS) is a neurologic autoimmune disorder featured by chronic
inflammation of the central nervous system, demyelination and axonal damage. Recently …

Withametelin, a novel phytosterol, alleviates neurological symptoms in EAE mouse model of multiple sclerosis via modulation of Nrf2/HO-1 and TLR4/NF-κB signaling

A Khan, B Shal, AU Khan, T Bibi, S ul Islam… - Neurochemistry …, 2021 - Elsevier
Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central
nervous system (CNS) that remains incurable. Withametelin (WMT), a phytosterol, showed …

Efficacy of probiotics in multiple sclerosis: a systematic review of preclinical trials and meta-analysis of randomized controlled trials

J Jiang, C Chu, C Wu, C Wang, C Zhang, T Li… - Food & Function, 2021 - pubs.rsc.org
Preliminary evidence shows the potential role of probiotics in ameliorating multiple sclerosis
(MS); however, the effects of probiotics on MS remain unclear. Therefore, the aim of this …

RETRACTED ARTICLE: Magnolol prevented brain injury through the modulation of Nrf2-dependent oxidative stress and apoptosis in PLP-induced mouse model of …

T Bibi, A Khan, AU Khan, B Shal, H Ali, EK Seo… - Naunyn-Schmiedeberg's …, 2022 - Springer
Multiple sclerosis (MS) is an immune-mediated chronic inflammatory demyelinating disease
of the central nervous system (CNS). The aim of the current study was to investigate the …

Matrine mediated neuroprotective potential in experimental multiple sclerosis: evidence from CSF, blood markers, brain samples and in-silico investigations

S Chhabra, S Mehan, Z Khan, GD Gupta… - Journal of …, 2023 - Elsevier
Multiple sclerosis (MS) is a debilitating, inflammatory, and demyelinating disease of the
central nervous system influenced by environmental and genetic factors. Around 2.8 million …

Modulation of the HMGB1/TLR4/NF-κB signaling pathway in the CNS by matrine in experimental autoimmune encephalomyelitis

Y Chu, Y Jing, X Zhao, M Wang, M Zhang, R Ma… - Journal of …, 2021 - Elsevier
The inflammatory mediator high-mobility group box 1 (HMGB1)-induced signaling pathway
has been shown to play an important role in the pathogenesis of multiple sclerosis (MS) and …

Research progress on the pharmacological effects of matrine

Y Sun, L Xu, Q Cai, M Wang, X Wang… - Frontiers in …, 2022 - frontiersin.org
Matrine possesses anti-cancer properties, as well as the prevention and treatment of allergic
asthma, and protection against cerebral ischemia-reperfusion injury. Its mechanism of action …

Effect of Naoluoxintong on the NogoA/RhoA/ROCK pathway by down-regulating DNA methylation in MCAO rats

L Hong, W Chen, L He, H Tan, D Peng, G Zhao… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance Naoluoxintong (NLXT) is a traditional Chinese Medicine
(TCM) prescription that is clinically used in the treatment of ischemic stroke (IS). However, its …