The phospholipase A2 superfamily: structure, isozymes, catalysis, physiologic and pathologic roles

SA Khan, MA Ilies - International journal of molecular sciences, 2023 - mdpi.com
The phospholipase A2 (PLA2) superfamily of phospholipase enzymes hydrolyzes the ester
bond at the sn-2 position of the phospholipids, generating a free fatty acid and a …

Lipid Droplets, Phospholipase A2, Arachidonic Acid, and Atherosclerosis

MA Bermúdez, MA Balboa, J Balsinde - Biomedicines, 2021 - mdpi.com
Lipid droplets, classically regarded as static storage organelles, are currently considered as
dynamic structures involved in key processes of lipid metabolism, cellular homeostasis and …

[HTML][HTML] A multi-omics based anti-inflammatory immune signature characterizes long COVID-19 syndrome

JJ Kovarik, A Bileck, G Hagn, SM Meier-Menches… - Iscience, 2023 - cell.com
To investigate long COVID-19 syndrome (LCS) pathophysiology, we performed an
exploratory study with blood plasma derived from three groups: 1) healthy vaccinated …

The role of polyunsaturated fatty acids in neuronal signaling in depression and cognitive processes

K Stachowicz - Archives of Biochemistry and Biophysics, 2023 - Elsevier
This study aimed to evaluate research findings on the role of polyunsaturated fatty acids
(PUFAs) in neuronal signaling. Polyunsaturated fatty acids (PUFAs) are the building blocks …

Anti-Inflammatory Effects of Phytochemical Components of Clinacanthus nutans

WY Ong, DR Herr, GY Sun, TN Lin - Molecules, 2022 - mdpi.com
Recent studies on the ethnomedicinal use of Clinacanthus nutans suggest promising anti-
inflammatory, anti-tumorigenic, and antiviral properties for this plant. Extraction of the leaves …

Molecular pharmacology of inflammation resolution in atherosclerosis

S Kotlyarov, A Kotlyarova - International Journal of Molecular Sciences, 2022 - mdpi.com
Atherosclerosis is one of the most important problems of modern medicine as it is the
leading cause of hospitalizations, disability, and mortality. The key role in the development …

A review of oxylipins in Alzheimer's disease and related dementias (ADRD): potential therapeutic targets for the modulation of vascular tone and inflammation

LH Shinto, J Raber, A Mishra, N Roese, LC Silbert - Metabolites, 2022 - mdpi.com
There is now a convincing body of evidence from observational studies that the majority of
modifiable Alzheimer's disease and related dementia (ADRD) risk factors are vascular in …

Functions and mechanisms of cytosolic phospholipase A2 in central nervous system trauma

HJ Zhang, YT Chen, XL Hu, WT Cai… - Neural regeneration …, 2023 - journals.lww.com
Central nervous system (CNS) trauma, including traumatic brain injury and spinal cord
injury, has a high rate of disability and mortality, and effective treatment is currently lacking …

COVID-19, blood lipid changes, and thrombosis

AA Farooqui, T Farooqui, GY Sun, TN Lin, DBL Teh… - Biomedicines, 2023 - mdpi.com
Although there is increasing evidence that oxidative stress and inflammation induced by
COVID-19 may contribute to increased risk and severity of thromboses, the underlying …

Mass spectrometry imaging highlights dynamic patterns of lipid co‐expression with Aβ plaques in mouse and human brains

HX Huang, P Inglese, J Tang, R Yagoubi… - Journal of …, 2024 - Wiley Online Library
Lipids play crucial roles in the susceptibility and brain cellular responses to Alzheimer's
disease (AD) and are increasingly considered potential soluble biomarkers in cerebrospinal …