Mechanisms of cancer resistance in long-lived mammals

A Seluanov, VN Gladyshev, J Vijg… - Nature Reviews Cancer, 2018 - nature.com
Cancer researchers have traditionally used the mouse and the rat as staple model
organisms. These animals are very short-lived, reproduce rapidly and are highly prone to …

The genetics of aging: a vertebrate perspective

PP Singh, BA Demmitt, RD Nath, A Brunet - Cell, 2019 - cell.com
Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …

Distinct longevity mechanisms across and within species and their association with aging

A Tyshkovskiy, S Ma, AV Shindyapina, S Tikhonov… - Cell, 2023 - cell.com
Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

DNA methylation predicts age and provides insight into exceptional longevity of bats

GS Wilkinson, DM Adams, A Haghani, AT Lu… - Nature …, 2021 - nature.com
Exceptionally long-lived species, including many bats, rarely show overt signs of aging,
making it difficult to determine why species differ in lifespan. Here, we use DNA methylation …

Six reference-quality genomes reveal evolution of bat adaptations

D Jebb, Z Huang, M Pippel, GM Hughes… - Nature, 2020 - nature.com
Bats possess extraordinary adaptations, including flight, echolocation, extreme longevity
and unique immunity. High-quality genomes are crucial for understanding the molecular …

The Egyptian rousette genome reveals unexpected features of bat antiviral immunity

SS Pavlovich, SP Lovett, G Koroleva, JC Guito… - Cell, 2018 - cell.com
Bats harbor many viruses asymptomatically, including several notorious for causing extreme
virulence in humans. To identify differences between antiviral mechanisms in humans and …

[HTML][HTML] The world goes bats: living longer and tolerating viruses

V Gorbunova, A Seluanov, BK Kennedy - Cell Metabolism, 2020 - cell.com
For centuries, people believed that bats possessed sinister powers. Bats are thought to be
ancestral hosts to many deadly viruses affecting humans including Ebola, rabies, and most …

The Genome 10K Project: a way forward

KP Koepfli, B Paten… - Annu. Rev. Anim …, 2015 - annualreviews.org
The Genome 10K Project was established in 2009 by a consortium of biologists and
genome scientists determined to facilitate the sequencing and analysis of the complete …

TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

M Sulak, L Fong, K Mika, S Chigurupati, L Yon… - elife, 2016 - elifesciences.org
A major constraint on the evolution of large body sizes in animals is an increased risk of
developing cancer. There is no correlation, however, between body size and cancer risk …

[图书][B] Bats of Britain and Europe

C Dietz, A Kiefer - 2016 - books.google.com
The definitive guide to the bats of Britain and Europe. This concise and definitive guide
presents all 45 bat species that regularly occur in Europe (of which 17 are known to breed in …