The dopaminergic system plays important roles in neuromodulation, such as motor control,
motivation, reward, cognitive function, maternal, and reproductive behaviors. Dopamine is a …

Dopamine (DA), as one of the major neurotransmitters in the central nervous system (CNS)
and periphery, exerts its actions through five types of receptors which belong to two major …

Abstract Background This Phase III, randomized, double-blind, placebo-controlled study
investigated the efficacy and tolerability of flexibly-dosed cariprazine in patients with acute …

Dopamine (DA) is a crucial neurotransmitter that plays an important role in maintaining
physiological function in human body. In the past, most studies focused on the relationship …

Cariprazine is an oral antipsychotic approved in the US and EU for the treatment of
schizophrenia. Cariprazine differs from other antipsychotics in that it is a dopamine D3-and …

Congenital hyperinsulinism (HI) is a genetic disorder in which pancreatic β-cell insulin
secretion is excessive and results in hypoglycemia that, without treatment, can cause brain …

Background: Neurons in the ventral tegmental area (VTA) are sensitive to stress and their
maladaptation have been implicated in the psychiatric disorders such as anxiety and …

Rationale Aberrant glutamatergic, dopaminergic, and GABAergic neurotransmission has
been implicated in schizophrenia. Cariprazine reverses the behavioral effects observed in …

G-protein coupled receptors (GPCRs) are considered important therapeutic targets due to
their pathophysiological significance and pharmacological relevance. Class A receptors …

Investigations on functional selectivity of GPCR ligands have become increasingly important
to identify compounds with a potentially more beneficial side effect profile. In order to …