11-Oxygenated androgens in health and disease
The adrenal gland is a source of sex steroid precursors, and its activity is particularly
relevant during fetal development and adrenarche. Following puberty, the synthesis of …
relevant during fetal development and adrenarche. Following puberty, the synthesis of …
[HTML][HTML] Intracrine androgen biosynthesis, metabolism and action revisited
Androgens play an important role in metabolic homeostasis and reproductive health in both
men and women. Androgen signalling is dependent on androgen receptor activation, mostly …
men and women. Androgen signalling is dependent on androgen receptor activation, mostly …
Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia
RJ Auchus, O Hamidi, R Pivonello… - … England Journal of …, 2024 - Mass Medical Soc
Background Adrenal insufficiency in patients with classic 21-hydroxylase deficiency
congenital adrenal hyperplasia (CAH) is treated with glucocorticoid replacement therapy …
congenital adrenal hyperplasia (CAH) is treated with glucocorticoid replacement therapy …
Management of endocrine disease: diagnosis and management of the patient with non-classic CAH due to 21-hydroxylase deficiency
A Nordenström, H Falhammar - European journal of …, 2019 - academic.oup.com
Non-classic congenital adrenal hyperplasia (NCAH) is a relatively common disorder
regardless of ethnicity, but most cases are never diagnosed, especially in males. A baseline …
regardless of ethnicity, but most cases are never diagnosed, especially in males. A baseline …
Testicular adrenal rest tumors: current insights on prevalence, characteristics, origin, and treatment
M Engels, PN Span, AE van Herwaarden… - Endocrine …, 2019 - academic.oup.com
This review provides the reader with current insights on testicular adrenal rest tumors
(TARTs), a complication in male patients with congenital adrenal hyperplasia (CAH). In …
(TARTs), a complication in male patients with congenital adrenal hyperplasia (CAH). In …
A new dawn for androgens: novel lessons from 11-oxygenated C19 steroids
E Pretorius, W Arlt, KH Storbeck - Molecular and cellular endocrinology, 2017 - Elsevier
The abundant adrenal C19 steroid 11β-hydroxyandrostenedione (11OHA4) has been
written off as a dead-end product of adrenal steroidogenesis. However, recent evidence has …
written off as a dead-end product of adrenal steroidogenesis. However, recent evidence has …
[PDF][PDF] Phase 3 Trial of Crinecerfont in Pediatric Congenital Adrenal Hyperplasia
BACKGROUND Children with classic congenital adrenal hyperplasia (CAH) due to 21-
hydroxylase deficiency require treatment with glucocorticoids, usually at supraphysiologic …
hydroxylase deficiency require treatment with glucocorticoids, usually at supraphysiologic …
Clinical perspectives in congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase type 2 deficiency
AM Al Alawi, A Nordenström, H Falhammar - Endocrine, 2019 - Springer
Purpose 3β-hydroxysteroid dehydrogenase type 2 deficiency (3βHSD2D) is a very rare
variant of congenital adrenal hyperplasia (CAH) causing less than 0.5% of all CAH. The aim …
variant of congenital adrenal hyperplasia (CAH) causing less than 0.5% of all CAH. The aim …
The interplay between stress, circadian clocks, and energy metabolism
H Oster - Journal of Endocrinology, 2020 - joe.bioscientifica.com
Endogenous circadian clocks adapt an organism's physiology and behavior to predictable
changes in the environment as a consequence of the Earth's rotation around its axis. In …
changes in the environment as a consequence of the Earth's rotation around its axis. In …
GC/MS in recent years has defined the normal and clinically disordered steroidome: will it soon be surpassed by LC/tandem MS in this role?
Gas chromatography/mass spectrometry (GC/MS) has been used for steroid analysis since
the 1960s. The advent of protective derivatization, capillary columns, and inexpensive …
the 1960s. The advent of protective derivatization, capillary columns, and inexpensive …