Mesenchymal stem/stromal cell-derived exosomes for immunomodulatory therapeutics and skin regeneration

DH Ha, H Kim, J Lee, HH Kwon, GH Park, SH Yang… - Cells, 2020 - mdpi.com
Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …

Technologies and standardization in research on extracellular vesicles

S Gandham, X Su, J Wood, AL Nocera, SC Alli… - Trends in …, 2020 - cell.com
Extracellular vesicles (EVs) are phospholipid bilayer membrane-enclosed structures
containing RNAs, proteins, lipids, metabolites, and other molecules, secreted by various …

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the …

C Théry, KW Witwer, E Aikawa… - Journal of …, 2018 - Wiley Online Library
The last decade has seen a sharp increase in the number of scientific publications
describing physiological and pathological functions of extracellular vesicles (EVs), a …

Isolation, cultivation, and characterization of human mesenchymal stem cells

D Mushahary, A Spittler, C Kasper, V Weber… - Cytometry Part …, 2018 - Wiley Online Library
Mesenchymal stem cells (MSC) exhibit a high self‐renewal capacity, multilineage
differentiation potential and immunomodulatory properties. This set of exceptional features …

Technical challenges of working with extracellular vesicles

MI Ramirez, MG Amorim, C Gadelha, I Milic, JA Welsh… - Nanoscale, 2018 - pubs.rsc.org
Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with
potential applications in diagnosis, prognosis and therapeutic guidance in most pathological …

Mesenchymal stem cell-based cell-free strategies: safe and effective treatments for liver injury

C Hu, L Zhao, L Zhang, Q Bao, L Li - Stem Cell Research & Therapy, 2020 - Springer
Various hepatoxic factors, such as viruses, drugs, lipid deposition, and autoimmune
responses, induce acute or chronic liver injury, and 3.5% of all worldwide deaths result from …

Single extracellular vesicle analysis for early cancer detection

S Ferguson, KS Yang, R Weissleder - Trends in molecular medicine, 2022 - cell.com
Extracellular vesicles (EVs) are actively shed into the circulation from both cancer and host
cells. EVs are emerging as one of the diagnostic frontrunners for early cancer detection …

Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate …

A Datta, H Kim, M Lal, L McGee, A Johnson… - Cancer letters, 2017 - Elsevier
Emerging evidence links exosomes to cancer progression by the trafficking of oncogenic
factors and neoplastic reprogramming of stem cells. This necessitates identification and …

Lab-on-chip for exosomes and microvesicles detection and characterization

MS Chiriacò, M Bianco, A Nigro, E Primiceri, F Ferrara… - Sensors, 2018 - mdpi.com
Interest in extracellular vesicles and in particular microvesicles and exosomes, which are
constitutively produced by cells, is on the rise for their huge potential as biomarkers in a high …

Exercise-induced circulating extracellular vesicles protect against cardiac ischemia–reperfusion injury

Y Bei, T Xu, D Lv, P Yu, J Xu, L Che, A Das… - Basic research in …, 2017 - Springer
Extracellular vesicles (EVs) serve an important function as mediators of intercellular
communication. Exercise is protective for the heart, although the signaling mechanisms that …