Hepatocellular carcinoma (HCC) is one of the most common and lethal malignant tumors in
the world. Therapeutic options for advanced HCC are limited. Systemic treatment, especially …

Hepatocellular carcinoma (HCC) is a complex biological process and is often diagnosed at
advanced stages with no effective treatment options. With advances in tumor biology and …

Angiogenesis, or the formation of new capillary blood vessels, occurs primarily during
human development and reproduction; however, aberrant regulation of angiogenesis is also …

Angiogenesis, a critical driver of tumor development, is controlled by interconnected
signaling pathways. Vascular endothelial growth factor receptor (VEGFR) 2 and tyrosine …

Photodynamic therapy (PDT) is a light-triggered therapy used to kill cancer cells by
producing reactive oxygen species (ROS). Herein, a new kind of DNA nanostructure based …

Background No effective systemic therapy exists for patients with advanced hepatocellular
carcinoma. A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the …

Although patients with advanced refractory solid tumors have poor prognosis, the clinical
development of targeted protein kinase inhibitors offers hope for the future treatment of many …

The rapid development of CRISPR/Cas9 systems has opened up tantalizing prospects to
sensitize cancers to chemotherapy using efficient targeted genome editing, but safety …

Background: Glutathione (GSH), the primary antioxidant in cells, could fight against oxidative
stress. Tumor cells display a higher GSH level than normal cells for coping with the …

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths.
Unfortunately, there is still no completely effective treatment. Ferroptosis could affect the …