Leukocyte migration through activated venular walls is a fundamental immune response that
is prerequisite to the entry of effector cells such as neutrophils, monocytes, and effector T …

Macrophages are a heterogeneous group of cells that are capable of carrying out distinct
functions in different tissues, as well as in different locations within a given tissue. Some of …

Iron is an essential element for multiple fundamental biological processes required for life;
yet iron overload can be cytotoxic. Consequently, iron concentrations at the cellular and …

Tissue-specific autoimmune diseases are driven by activation of diverse immune cells in the
target organs. However, the molecular signatures of immune cell populations over time in an …

Leukocyte extravasation is one of the essential and first steps during the initiation of
inflammation. Therefore, a better understanding of the key molecules that regulate this …

Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor
resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that …

The microbiome is a complex community of Bacteria, Archaea, Eukarya, and viruses that
infect humans and live in our tissues. It contributes the majority of genetic information to our …

We examined the transcriptional profiles of macrophages that reside in the islets of
Langerhans of 3-wk-old non-obese diabetic (NOD), NOD. Rag1−/−, and B6. g7 mice. Islet …

Beta cells from nondiabetic mice transfer secretory vesicles to phagocytic cells. The passage
was shown in culture studies where the transfer was probed with CD4 T cells reactive to …

Recent advances in immunotherapeutics have not yet changed the routine management of
autoimmune type 1 diabetes. There is an opportunity to repurpose therapeutics used to treat …