Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …

Astrocytes play essential roles in development, homeostasis, injury, and repair of the central
nervous system (CNS). Their development is tightly regulated by distinct spatial and …

The generation of astrocytes from human induced pluripotent stem cells has been hampered
by either prolonged differentiation—spanning over two months—or by shorter protocols that …

Induced pluripotent stem cell (iPSC)-based disease modeling has a great potential for
uncovering the mechanisms of pathogenesis, especially in the case of neurodegenerative …

Pluripotent stem cells (PSCs) are highly proliferative cells characterized by robust metabolic
demands to power rapid division. For many years considered a passive component or" …

Rett syndrome (RTT) is a severe neurological disorder, with impaired brain development
caused by mutations in MECP2; however, the underlying mechanism remains elusive. We …

Rett syndrome (RTT) is a rare, X-linked neurodevelopmental disorder typically affecting
females, resulting in a range of symptoms including autistic features, intellectual impairment …

In the developing brain, the three major cell types, ie, neurons, astrocytes and
oligodendrocytes, are generated from common multipotent neural stem cells (NSCs). In …

Normoxia is defined as an oxygen concentration of 20.9%, as in room air, whereas hypoxia
refers to any oxygen concentration less than this. Any physiological oxygen deficiency or …

Studies linking mutations in Methyl CpG Binding Protein 2 (MeCP2) to physiological defects
in the neurological disease, Rett syndrome, have focused largely upon neuronal dysfunction …