Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

Neuronal cells are highly functioning but also extremely stress-sensitive cells. By defending
the neuronal cells against pathogenic insults, microglial cells, a unique cell type, act as the …

Microglial reactivity to injury and disease is emerging as a heterogeneous, dynamic, and
crucial determinant in neurological disorders. However, the plasticity and fate of disease …

Non-neuronal cells are key to the complex cellular interplay that follows central nervous
system insult. To understand this interplay, we generated a single-cell atlas of immune, glial …

Spinal cord injury (SCI) is a devastating condition with no curative therapy currently
available. Immunomodulation can be applied as a therapeutic strategy to drive alternative …

Axonal regeneration and functional recovery are poor after spinal cord injury (SCI), typified
by the formation of an injury scar. While this scar was traditionally believed to be primarily …

Current treatments for modulating the glial‐mediated inflammatory response after spinal
cord injury (SCI) have limited ability to improve recovery. This is quite likely due to the lack of …

Background A growing body of research shows that drug monomers from traditional
Chinese herbal medicines have antineuroinflammatory and neuroprotective effects that can …