Genetics of anti-Müllerian hormone and its signaling pathway

N Josso, JY Picard - Best Practice & Research Clinical Endocrinology & …, 2022 - Elsevier
Anti-Müllerian hormone (AMH) is a member of the TGF-β family produced essentially by the
supporting somatic cells of the testis. Initially known for its inhibiting role upon the …

[HTML][HTML] Sexual differentiation

R Rey, N Josso, C Racine - Endotext [internet], 2020 - ncbi.nlm.nih.gov
The chromosomal sex of the embryo is established at fertilization. However, 6 weeks elapse
in humans before the first signs of sex differentiation are noticed. Sex differentiation involves …

AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy

M Kano, AE Sosulski, LH Zhang… - Proceedings of the …, 2017 - National Acad Sciences
The ovarian reserve represents the stock of quiescent primordial follicles in the ovary which
is gradually depleted during a woman's reproductive lifespan, resulting in menopause …

A single-cell atlas of the cycling murine ovary

ME Morris, MC Meinsohn, M Chauvin, HD Saatcioglu… - Elife, 2022 - elifesciences.org
The estrous cycle is regulated by rhythmic endocrine interactions of the nervous and
reproductive systems, which coordinate the hormonal and ovulatory functions of the ovary …

Durable contraception in the female domestic cat using viral-vectored delivery of a feline anti-Müllerian hormone transgene

LM Vansandt, MC Meinsohn, P Godin… - Nature …, 2023 - nature.com
Eighty percent of the estimated 600 million domestic cats in the world are free-roaming.
These cats typically experience suboptimal welfare and inflict high levels of predation on …

Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-β family

KN Hart, WA Stocker, NG Nagykery… - Proceedings of the …, 2021 - National Acad Sciences
Anti-Müllerian hormone (AMH), or Müllerian-inhibiting substance, is a protein hormone that
promotes Müllerian duct regression during male fetal sexual differentiation and regulation of …

[HTML][HTML] Cancer-associated mesothelial cells are regulated by the anti-Müllerian hormone axis

M Chauvin, MC Meinsohn, S Dasari, P May, S Iyer… - Cell Reports, 2023 - cell.com
Cancer-associated mesothelial cells (CAMCs) in the tumor microenvironment are thought to
promote growth and immune evasion. We find that, in mouse and human ovarian tumors …

Challenges in measuring AMH in the clinical setting

HWR Li, DM Robertson, C Burns… - Frontiers in …, 2021 - frontiersin.org
Serum anti-Mullerian hormone (AMH) is a widely used marker of functional ovarian reserve
in the assessment and treatment of infertility. It is used to determine dosing of gonadotropins …

Single-cell sequencing of neonatal uterus reveals an Misr2+ endometrial progenitor indispensable for fertility

HD Saatcioglu, M Kano, H Horn, L Zhang, W Samore… - elife, 2019 - elifesciences.org
The Mullerian ducts are the anlagen of the female reproductive tract, which regress in the
male fetus in response to MIS. This process is driven by subluminal mesenchymal cells …

A screen of repurposed drugs identifies AMHR2/MISR2 agonists as potential contraceptives

Y Li, L Wei, MC Meinsohn, R Suliman… - Proceedings of the …, 2022 - National Acad Sciences
We identified the anti-Mullerian hormone (also known as Müllerian inhibiting substance or
MIS) as an inhibitory hormone that induces long-term contraception in mammals. The type II …