Strategies for long-term preservation of kidney graft function

T Wekerle, D Segev, R Lechler, R Oberbauer - The Lancet, 2017 - thelancet.com
Kidney transplantation has become a routine procedure in the treatment of patients with
kidney failure, and requires collaboration of experts from different disciplines, such as …

The therapeutic challenge of late antibody‐mediated kidney allograft rejection

GA Böhmig, F Eskandary, K Doberer… - Transplant …, 2019 - Wiley Online Library
Late antibody‐mediated rejection (ABMR) is a cardinal cause of kidney allograft failure,
manifesting as a continuous and, in contrast with early rejection, often clinically silent …

A randomized trial of bortezomib in late antibody-mediated kidney transplant rejection

F Eskandary, H Regele, L Baumann… - Journal of the …, 2018 - journals.lww.com
Late antibody-mediated rejection (ABMR) is a leading cause of kidney allograft failure.
Uncontrolled studies have suggested efficacy of the proteasome inhibitor bortezomib, but no …

[HTML][HTML] Absolute quantification of donor-derived cell-free DNA as a marker of rejection and graft injury in kidney transplantation: Results from a prospective …

M Oellerich, M Shipkova, T Asendorf, PD Walson… - American journal of …, 2019 - Elsevier
Donor-derived cell-free DNA (dd-cfDNA) is a noninvasive biomarker for comprehensive
monitoring of allograft injury and rejection in kidney transplantation (KTx). dd-cfDNA …

[HTML][HTML] Antibody-mediated rejection: new approaches in prevention and management

RA Montgomery, A Loupy, DL Segev - American Journal of Transplantation, 2018 - Elsevier
Despite the success of desensitization protocols, antibody-mediated rejection (AMR)
remains a significant contributor to renal allograft failure in patients with donor-specific …

[HTML][HTML] Assessing rejection-related disease in kidney transplant biopsies based on archetypal analysis of molecular phenotypes

J Reeve, GA Böhmig, F Eskandary, G Einecke… - JCI insight, 2017 - ncbi.nlm.nih.gov
Conventional histologic diagnosis of rejection in kidney transplants has limited repeatability
due to its inherent requirement for subjective assessment of lesions, in a rule-based system …

Non-HLA antibodies and epitope mismatches in kidney transplant recipients with histological antibody-mediated rejection

M Crespo, L Llinàs-Mallol, D Redondo-Pachón… - Frontiers in …, 2021 - frontiersin.org
Background Correlation between antibody-mediated rejection (ABMR) and circulating HLA
donor-specific antibodies (HLA-DSA) is strong but imperfect in kidney transplant (KT) …

[HTML][HTML] Generating automated kidney transplant biopsy reports combining molecular measurements with ensembles of machine learning classifiers

J Reeve, GA Böhmig, F Eskandary, G Einecke… - American Journal of …, 2019 - Elsevier
We previously reported a system for assessing rejection in kidney transplant biopsies using
microarray-based gene expression data, the Molecular Microscope® Diagnostic System …

Torque Teno virus load—inverse association with antibody-mediated rejection after kidney transplantation

M Schiemann, E Puchhammer-Stöckl… - …, 2017 - journals.lww.com
Background Antibody-mediated rejection (AMR) represents one of the cardinal causes of
late allograft loss after kidney transplantation, and there is great need for noninvasive tools …

[HTML][HTML] Anti-C1s monoclonal antibody BIVV009 in late antibody-mediated kidney allograft rejection—results from a first-in-patient phase 1 trial

F Eskandary, B Jilma, J Mühlbacher… - American Journal of …, 2018 - Elsevier
The classical pathway (CP) of complement may contribute to the pathogenesis of antibody-
mediated rejection (ABMR). Selective CP blockade may be a promising strategy to …