Plasminogen-binding proteins as an evasion mechanism of the host's innate immunity in infectious diseases

DA Ayón-Núñez, G Fragoso, RJ Bobes… - Bioscience …, 2018 - portlandpress.com
Pathogens have developed particular strategies to infect and invade their hosts. Amongst
these strategies' figures the modulation of several components of the innate immune system …

Enolase: a key player in the metabolism and a probable virulence factor of trypanosomatid parasites—perspectives for its use as a therapeutic target

L Avilán, M Gualdrón-López, W Quiñones… - Enzyme …, 2011 - Wiley Online Library
Glycolysis and glyconeogenesis play crucial roles in the ATP supply and synthesis of
glycoconjugates, important for the viability and virulence, respectively, of the human …

Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgut

AK Ghosh, I Coppens, H Gårdsvoll… - Proceedings of the …, 2011 - National Acad Sciences
Ookinete invasion of the mosquito midgut is an essential step for the development of the
malaria parasite in the mosquito. Invasion involves recognition between a presumed …

The oligopeptidase B of Leishmania regulates parasite enolase and immune evasion

RK Swenerton, S Zhang, M Sajid… - Journal of Biological …, 2011 - ASBMB
Proteases are a ubiquitous group of enzymes that play key roles in the life cycle of parasites,
in the host-parasite relationship, and in the pathogenesis of parasitic diseases. Furthermore …

Extracellular functions of glycolytic enzymes of parasites: unpredicted use of ancient proteins

A Gómez-Arreaza, H Acosta, W Quiñones… - Molecular and …, 2014 - Elsevier
In addition of their usual intracellular localization where they are involved in catalyzing
reactions of carbohydrate and energy metabolism by glycolysis, multiple studies have …

Moonlighting proteins as virulence factors of pathogenic fungi, parasitic protozoa and multicellular parasites

J Karkowska‐Kuleta, A Kozik - Molecular Oral Microbiology, 2014 - Wiley Online Library
The delicate balance between eukaryotic pathogens and their human hosts during the
initiation and development of infection is a complex process involving many diverse …

Enolase as a plasminogen binding protein in Leishmania mexicana

G Vanegas, W Quiñones, C Carrasco-López… - Parasitology …, 2007 - Springer
Enolase is a glycolytic and gluconeogenic enzyme also found on the surface of several
eukaryotic and prokaryotic cells where it acts as plasminogen binding protein. Leishmania …

Proteins selected in Leishmania (Viannia) braziliensis by an immunoproteomic approach with potential serodiagnosis applications for tegumentary leishmaniasis

MC Duarte, DC Pimenta… - Clinical and Vaccine …, 2015 - Am Soc Microbiol
The serodiagnosis of human tegumentary leishmaniasis (TL) presents some problems, such
as the low level of antileishmanial antibodies found in most of the patients, as well as the …

Surface-expressed enolases of Plasmodium and other pathogens

AK Ghosh, M Jacobs-Lorena - Memorias do Instituto Oswaldo Cruz, 2011 - SciELO Brasil
Enolase is the eighth enzyme in the glycolytic pathway, a reaction that generates ATP from
phosphoenol pyruvate in cytosolic compartments. Enolase is essential, especially for …

[PDF][PDF] The role of enolase in tissue invasion and metastasis of pathogens and tumor cells

KJ Liu, NY Shih - J Cancer Mol, 2007 - Citeseer
Recent studies have revealed that a glycolytic enzyme, enolase (ENO), is involved in many
different physiological and pathophysiological conditions. ENO can be detected in many …