Short chain fatty acids as potential therapeutic agents in human gastrointestinal and inflammatory disorders

PA Gill, MC Van Zelm, JG Muir… - Alimentary …, 2018 - Wiley Online Library
Background Butyrate, propionate and acetate are short chain fatty acids (SCFA), important
for maintaining a healthy colon and are considered as protective in colorectal …

[HTML][HTML] Microbiota-gut-brain axis: modulator of host metabolism and appetite

M Van de Wouw, H Schellekens, TG Dinan… - The Journal of nutrition, 2017 - Elsevier
The gut harbors an enormous diversity of microbes that are essential for the maintenance of
homeostasis in health and disease. A growing body of evidence supports the role of this …

Dietary supplementation with inulin-propionate ester or inulin improves insulin sensitivity in adults with overweight and obesity with distinct effects on the gut …

ES Chambers, CS Byrne, DJ Morrison, KG Murphy… - Gut, 2019 - gut.bmj.com
Objective To investigate the underlying mechanisms behind changes in glucose
homeostasis with delivery of propionate to the human colon by comprehensive and …

Clinical translation of advanced colonic drug delivery technologies

A Awad, CM Madla, LE McCoubrey, F Ferraro… - Advanced drug delivery …, 2022 - Elsevier
Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local
diseases, direct access to unique therapeutic targets and the potential for increasing …

The diet‐derived short chain fatty acid propionate improves beta‐cell function in humans and stimulates insulin secretion from human islets in vitro

A Pingitore, ES Chambers, T Hill… - Diabetes, Obesity …, 2017 - Wiley Online Library
Aims Diet‐derived short chain fatty acids (SCFAs) improve glucose homeostasis in vivo, but
the role of individual SCFAs and their mechanisms of action have not been defined. This …

Dynamic balancing of intestinal short-chain fatty acids: The crucial role of bacterial metabolism

Y Xu, Y Zhu, X Li, B Sun - Trends in Food Science & Technology, 2020 - Elsevier
Background Short-chain fatty acids (SCFAs) play important physiological roles in human
health. Adverse effects on health are known with a low or excessive concentration of SCFAs …

[HTML][HTML] Role of microbiota short-chain fatty acids in the pathogenesis of autoimmune diseases

A Rasouli-Saravani, K Jahankhani, S Moradi… - Biomedicine & …, 2023 - Elsevier
There is emerging evidence that microbiota and its metabolites play an important role in
helath and diseases. In this regard, gut microbiota has been found as a crucial component …

Influence of the gut microbiota on satiety signaling

JJAJ Bastings, K Venema, EE Blaak… - Trends in Endocrinology & …, 2023 - cell.com
Recent studies show a link between the gut microbiota and the regulation of satiety and
energy intake, processes that contribute to the development and pathophysiology of …

Gut microbiota interaction with the central nervous system throughout life

J Ojeda, A Ávila, PM Vidal - Journal of Clinical Medicine, 2021 - mdpi.com
During the last years, accumulating evidence has suggested that the gut microbiota plays a
key role in the pathogenesis of neurodevelopmental and neurodegenerative diseases via …

Efficiency of resistant starch and dextrins as prebiotics: a review of the existing evidence and clinical trials

M Włodarczyk, K Śliżewska - Nutrients, 2021 - mdpi.com
In well-developed countries, people have started to pay additional attention to preserving
healthy dietary habits, as it has become common knowledge that neglecting them may …