Current status and future prospects in cannabinoid production through in vitro culture and synthetic biology

M Hesami, M Pepe, A Baiton, AMP Jones - Biotechnology Advances, 2023 - Elsevier
For centuries, cannabis has been a rich source of fibrous, pharmaceutical, and recreational
ingredients. Phytocannabinoids are the most important and well-known class of cannabis …

The role of microglia in neuropsychiatric disorders and suicide

R Brisch, S Wojtylak, A Saniotis, J Steiner… - European archives of …, 2022 - Springer
This narrative review examines the possible role of microglial cells, first, in
neuroinflammation and, second, in schizophrenia, depression, and suicide. Recent research …

[HTML][HTML] Enduring neurobiological consequences of early-life stress: Insights from rodent behavioral paradigms

L Speranza, KD Filiz, P Lippiello, MG Ferraro… - Biomedicines, 2024 - mdpi.com
Stress profoundly affects physical and mental health, particularly when experienced early in
life. Early-life stress (ELS) encompasses adverse childhood experiences such as abuse …

Weeding out the problem: the impact of preoperative cannabinoid use on pain in the perioperative period

CW Liu, A Bhatia, A Buzon-Tan, S Walker… - Anesthesia & …, 2019 - journals.lww.com
BACKGROUND: The recreational and medical use of cannabinoids has been increasing.
While most studies and reviews have focused on the role of cannabinoids in the …

Effects of cannabidiol on innate immunity: experimental evidence and clinical relevance

S Martini, A Gemma, M Ferrari, M Cosentino… - International Journal of …, 2023 - mdpi.com
Cannabidiol (CBD) is the main non-psychotropic cannabinoid derived from cannabis
(Cannabis sativa L., fam. Cannabaceae). CBD has received approval by the Food and Drug …

Cannabidiol improves cognitive impairment and reverses cortical transcriptional changes induced by ketamine, in schizophrenia-like model in rats

E Kozela, M Krawczyk, T Kos, A Juknat, Z Vogel… - Molecular …, 2020 - Springer
Abstract Cannabidiol (CBD), a non-psychotropic cannabinoid, demonstrates antipsychotic-
like and procognitive activities in humans and in animal models of schizophrenia. The …

Role of the endocannabinoid system in neurological disorders

M Zou, D Li, L Li, L Wu, C Sun - International Journal of Developmental …, 2019 - Elsevier
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that begins in
infancy. Although the etiology and pathogenesis are poorly understood, many studies have …

[HTML][HTML] The Role of Neuroglia in the Development and Progression of Schizophrenia

NS Rawani, AW Chan, KG Todd, GB Baker, SM Dursun - Biomolecules, 2024 - mdpi.com
Schizophrenia is a complex heterogenous disorder thought to be caused by interactions
between genetic and environmental factors. The theories developed to explain the etiology …

Cannabinoid receptor type 2 gene is associated with comorbidity of schizophrenia and cannabis dependence and fatty acid amide hydrolase gene is associated with …

F ARIAS HORCAJADAS, JR DÁVILA PÍRIZ… - …, 2023 - search.ebscohost.com
The endocannabinoid system has been associated with various psychiatric disorders, such
as schizophrenia or addictive disorders. Recent studies have found that some …

Neuroprotective and neurotoxic effects of endocannabinoid-like compounds, N-arachidonoyl dopamine and N-docosahexaenoyl dopamine in differentiated cultures of …

E Novosadova, S Antonov, E Arsenyeva, A Kobylanskiy… - Neurotoxicology, 2021 - Elsevier
The prominent protective effects in diverse neuron injury paradigms exerted by
cannabinoids and in particular their endogenously produced species render the …