Iron is biologically essential, but also potentially toxic; as such it is tightly controlled at cell
and systemic levels to prevent both deficiency and overload. Iron regulatory proteins post …

Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), polycythemia
vera, essential thrombocythemia, and primary myelofibrosis, are hematopoietic stem cell …

Low plasma iron (hypoferremia) induced by hepcidin is a conserved inflammatory response
that protects against infections but inhibits erythropoiesis. How hypoferremia influences …

Bacterial infections and antibiotic resistance have become a global healthcare crisis. There
is an urgent need to develop visualized therapeutic platforms that allow accurate imaging of …

Tumor-derived factors are thought to regulate thrombocytosis and erythrocytopenia in
individuals with cancer; however, such factors have not yet been identified. Here we show …

TMPRSS6 is a serine protease highly expressed in the liver. Its role in iron regulation was
first reported in 2008 when mutations in TMPRSS6 were shown to be the cause of iron …

Abstract JAK 2-V617F mutation causes myeloproliferative neoplasms (MPNs) that can
manifest as polycythemia vera (PV), essential thrombocythemia (ET), or primary …

Blood platelets have important roles in haemostasis, where they quickly stop bleeding in
response to vascular damage. They have also recognised functions in thrombosis, immunity …

The association of thrombocytosis with iron deficiency anemia (IDA) is well‐recognized, but
data describing the rate, predictors, and risk of thrombotic complications associated with IDA …

The role of iron in the formation and functioning of erythrocytes, and to a lesser degree of
white blood cells, is well established, but the relationship between iron and platelets is less …