Arachidonic acid-derived prostaglandins not only contribute to the development of
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Mechanical allodynia, induced by normally innocuous low-threshold mechanical stimulation,
represents a cardinal feature of neuropathic pain. Blockade or ablation of high-threshold …

The exteroceptive somatosensory system is important for reflexive and adaptive behaviors
and for the dynamic control of movement in response to external stimuli. This review outlines …

The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a
key component of pain and inflammation. A large amount of evidence shows that TRPV1 is …

The peripheral terminals of primary nociceptive neurons play an essential role in pain
detection mediated by membrane receptors like TRPV1, a molecular sensor of heat and …

Neuropathic pain is characterized by mechanical allodynia induced by low-threshold
myelinated Aβ-fiber activation. The original gate theory of pain proposes that inhibitory …

As the brain‐resident innate immune cells, reactive microglia are a major pathological
feature of Alzheimer's disease (AD). However, the exact role of microglia is still unclear in …

Chronic pain represents a major challenge to clinical practice and basic science. Excitatory
neurotransmission in somatosensory nociceptive pathways is predominantly mediated by …

Abnormal pain sensitivity is commonly associated with autism spectrum disorders (ASDs)
and affects the life quality of ASD individuals. SHANK3 deficiency was implicated in ASD …