Current developments of artificial intelligence in digital pathology and its future clinical applications in gastrointestinal cancers

ANN Wong, Z He, KL Leung, CCK To, CY Wong… - Cancers, 2022 - mdpi.com
Simple Summary The rapid development of technology has enabled numerous applications
of artificial intelligence (AI), especially in medical science. Histopathological assessment of …

HBx-induced HSPA8 stimulates HBV replication and suppresses ferroptosis to support liver cancer progression

Y Wang, M Zhao, L Zhao, Y Geng, G Li, L Chen, J Yu… - Cancer Research, 2023 - AACR
Hepatitis B virus (HBV) infection is a major driver of hepatocarcinogenesis. Ferroptosis is a
type of iron-mediated cell death that can suppress liver transformation. Previous studies …

Aspirin triggers ferroptosis in hepatocellular carcinoma cells through restricting NF-κB p65-activated SLC7A11 transcription

Y Wang, J Feng, L Zhao, M Zhao, X Wei… - Acta Pharmacologica …, 2023 - nature.com
A number of studies have shown that aspirin, as commonly prescribed drug, prevents the
development of hepatocellular carcinoma (HCC). Ferroptosis as a dynamic tumor …

In situ stable generation of reactive intermediates by open microfluidic probe for subcellular free radical attack and membrane labeling

Q Zhang, S Feng, W Li, T Xie… - Angewandte Chemie …, 2021 - Wiley Online Library
Subcellular stimulation by free radicals is crucial for deeper insight of cell behaviors.
However, it remains a tough challenge due to the high spatial precision requirement and …

Quantifying Antibody Binding Kinetics on Fixed Cells and Tissues via Fluorescence Lifetime Imaging

P Mathur, A Fomitcheva Khartchenko… - Analytical …, 2022 - ACS Publications
We present a method for monitoring spatially localized antigen–antibody binding events on
physiologically relevant substrates (cell and tissue sections) using fluorescence lifetime …

Inhibition of USP7 enhances CD8+ T cell activity in liver cancer by suppressing PRDM1-mediated FGL1 upregulation

L Sun, L Zhao, J Sun, H Yuan, Y Wang, C Hou… - Acta Pharmacologica …, 2024 - nature.com
Abstract Lymphocyte activation gene 3 (LAG3), an immune checkpoint molecule expressed
on activated T cells, functions as a negative regulator of immune responses. Persistent …

Graph Representation Learning and Explainability in Breast Cancer Pathology: Bridging the Gap between AI and Pathology Practice

P Pati, G Jaume… - … In Human Pathology, 2022 - books.google.com
According to the global cancer statistics released on December 14th, 2020, by the
International Agency for Research on Cancer (IARC), the estimated new breast cancer …

Rapid micro-immunohistochemistry

RD Lovchik, D Taylor, G Kaigala - Microsystems & Nanoengineering, 2020 - nature.com
We present a new and versatile implementation of rapid and localized immunohistochemical
staining of tissue sections. Immunohistochemistry (IHC) comprises a sequence of specific …

[PDF][PDF] Improved Antibody optimisation for tumour Analysis through the Combination of Machine Learning with New Molecular Assay

AF Khartchenko, A Kashyap - Digital Health, 2019 - academia.edu
The role of a pathologist is critical to the cancer diagnosis workflow: they need to understand
patient pathology and provide clinicians with insights through result interpretation. To do so …