Retinal ganglion cell (RGC) death is the principal consequence of injury to the optic nerve.
For several decades, we have understood that the RGC death process was executed by …

Ocular diseases associated with retinal ganglion cell (RGC) degeneration is the most
common neurodegenerative disorder that causes irreversible blindness worldwide. It is …

Loss of function following injury to the CNS is worsened by secondary degeneration of
neurons and glia surrounding the injury and is initiated by oxidative damage. However, it is …

Mapping mean axon diameter and intra-axonal volume fraction may have significant clinical
potential because nerve conduction velocity is directly dependent on axon diameter, and …

Advances over the past decade have improved our understanding of the role of sphingolipid
in the onset and progression of Parkinson's disease. Much attention has been paid to …

Glaucoma challenges the survival of retinal ganglion cell axons in the optic nerve through
processes dependent on both aging and ocular pressure. Relevant stressors likely include …

Reactive oxygen species (ROS) are implicated in a range of degenerative conditions,
including aging, neurodegenerative diseases, and neurological disorders. Myelin is a lipid …

Differentiation of oligodendrocyte progenitor cells (OPC) to oligodendrocytes and
subsequent axon myelination are critical steps in vertebrate central nervous system (CNS) …

Multiple system atrophy (MSA) is characterized by the presence of distinctive glial
cytoplasmic inclusions (GCIs) within oligodendrocytes that contain the neuronal protein …

In vitro peripheral nerve models provide valuable tools to study neurobiology questions and
assess drug performance, in a regenerative or pathology context. To this end, we have …