Membrane proteins (MPs) are usually handled in aqueous solutions as protein/detergent
complexes. Detergents, however, tend to be inactivating. This situation has prompted the …

Membrane proteins mediate a number of cellular functions and are associated with several
diseases and also play a crucial role in pathogenicity. Due to their importance in cellular …

US9751915B2 - Mutant pores - Google Patents US9751915B2 - Mutant pores - Google
Patents Mutant pores Download PDF Info Publication number US9751915B2 …

The translocation (T)-domain plays a key role in the action of diphtheria toxin and is
responsible for transferring the catalytic domain across the endosomal membrane into the …

Handling integral membrane proteins in aqueous solutions traditionally relies on the use of
detergents, which are surfactants capable of dispersing the components of biological …

The diphtheria toxin T domain translocates the catalytic C domain across the endosomal
membrane in response to acidification. To elucidate the role of histidine protonation in …

The pH-triggered membrane insertion pathway of the T-domain of diphtheria toxin was
studied using site-selective fluorescence labeling with subsequent application of several …

Lipid droplets are dynamic subcellular organelles that participate in a range of physiological
processes including metabolism, regulation and lipid storage. Their role in disease, such as …

The pH-triggered membrane insertion of the diphtheria toxin translocation domain (T
domain) results in transferring the catalytic domain into the cytosol, which is relevant to …

Diphtheria toxin is among many bacterial toxins that utilize the endosomal pathway of
cellular entry, which is ensured by the bridging of the endosomal membrane by the toxin's …